Total synthesis of homogeneous antifreeze glycopeptides and glycoproteins

Brendan L. Wilkinson, Robin S. Stone, Chantelle J. Capicciotti, Morten Thaysen-Andersen, Jacqueline M. Matthews, Nicolle H. Packer, Robert N. Ben, Richard J. Payne*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

100 Citations (Scopus)


Don't freeze! A native chemical ligation-desulfurization strategy has been employed for the convergent synthesis of a library of defined antifreeze glycopeptides and glycoproteins (AFGPs) ranging in size from 1.2 to 19.5 kDa (see picture). These AFGPs possessed the secondary structure of a polyproline type II helix and exhibited significant ice recrystallization inhibition and thermal hysteresis activity.

Original languageEnglish
Pages (from-to)3606-3610
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number15
Publication statusPublished - 10 Apr 2012


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