TY - JOUR
T1 - Total synthesis of homogeneous antifreeze glycopeptides and glycoproteins
AU - Wilkinson, Brendan L.
AU - Stone, Robin S.
AU - Capicciotti, Chantelle J.
AU - Thaysen-Andersen, Morten
AU - Matthews, Jacqueline M.
AU - Packer, Nicolle H.
AU - Ben, Robert N.
AU - Payne, Richard J.
PY - 2012/4/10
Y1 - 2012/4/10
N2 - Don't freeze! A native chemical ligation-desulfurization strategy has been employed for the convergent synthesis of a library of defined antifreeze glycopeptides and glycoproteins (AFGPs) ranging in size from 1.2 to 19.5 kDa (see picture). These AFGPs possessed the secondary structure of a polyproline type II helix and exhibited significant ice recrystallization inhibition and thermal hysteresis activity.
AB - Don't freeze! A native chemical ligation-desulfurization strategy has been employed for the convergent synthesis of a library of defined antifreeze glycopeptides and glycoproteins (AFGPs) ranging in size from 1.2 to 19.5 kDa (see picture). These AFGPs possessed the secondary structure of a polyproline type II helix and exhibited significant ice recrystallization inhibition and thermal hysteresis activity.
UR - http://www.scopus.com/inward/record.url?scp=84859540284&partnerID=8YFLogxK
U2 - 10.1002/anie.201108682
DO - 10.1002/anie.201108682
M3 - Article
C2 - 22389168
AN - SCOPUS:84859540284
SN - 1433-7851
VL - 51
SP - 3606
EP - 3610
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 15
ER -