TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses

Kim Guven, Peter Gunning, Thomas Fath*

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Synaptic function in the central nervous system (CNS) is highly dependent on a dynamic actin cytoskeleton in both the pre- and the postsynaptic compartment. Remodelling of the actin cytoskeleton is controlled by tropomyosins, a family of actin-associated proteins which define distinct actin filament populations. Here we show that TPM3 and TPM4 gene products localize to the postsynaptic region in mouse hippocampal neurons. Furthermore our data confirm previous findings of isoform segregation to the pre- and postsynaptic compartments at CNS synapses. These data provide fundamental insights in the formation of functionally distinct actin filament populations at the pre- and post-synapse.

Original languageEnglish
Pages (from-to)284-289
Number of pages6
JournalBioarchitecture
Volume1
Issue number6
DOIs
Publication statusPublished - 1 Jan 2011
Externally publishedYes

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Keywords

  • Actin cytoskeleton
  • Central nervous system
  • Postsynapse
  • Tropomyosin

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