Transbronchial lung cryobiopsy: a novel confirmatory tool to diagnose asbestos-related pulmonary fibrosis

Marta Zajaczkowska, Anthony Johnson, Luis Gallur, Joo Shin, Christopher Henderson, Jonathan Williamson

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Asbestosis is diagnosed with a combination of historical, clinical and radiological findings in the absence of another cause. Histology is required when uncertainty exists, with lung biopsy via VATs being gold standard. Transbronchial cryobiopsy is becoming increasingly popular for diagnosing interstitial lung disease and may provide sufficient lung sample to demonstrate asbestosis. A 73 year old man presented with dyspnoea on a background of rheumatoid arthritis, previous methotrexate use and asbestos exposure. Examination revealed fine crackles in the mid and lower zones bilaterally without signs of pulmonary hypertension. The presence of pleural plaques and basal interstitial reticulation on HRCT was suggestive of asbestosis but histology was required to differentiate this from rheumatoid or methotrexate associated ILD. Samples of lung tissue were obtained via transbronchial cryobiopsy, demonstrating fibrosis and asbestos fibres consistent with asbestosis. Transbronchial cryobiopsy appears effective in obtaining sufficient parenchymal lung samples to diagnose asbestosis when clinical uncertainty exists.

LanguageEnglish
Article numbere00380
Pages1-4
Number of pages4
JournalRespirology Case Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Asbestosis
Pulmonary Fibrosis
Asbestos
Lung
Methotrexate
Uncertainty
Histology
Interstitial Lung Diseases
Respiratory Sounds
Pulmonary Hypertension
Dyspnea
Rheumatoid Arthritis
Fibrosis
Biopsy

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Asbestos fibre count
  • asbestosis
  • cryobiopsy

Cite this

Zajaczkowska, Marta ; Johnson, Anthony ; Gallur, Luis ; Shin, Joo ; Henderson, Christopher ; Williamson, Jonathan. / Transbronchial lung cryobiopsy : a novel confirmatory tool to diagnose asbestos-related pulmonary fibrosis. In: Respirology Case Reports. 2019 ; Vol. 7, No. 1. pp. 1-4.
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Transbronchial lung cryobiopsy : a novel confirmatory tool to diagnose asbestos-related pulmonary fibrosis. / Zajaczkowska, Marta; Johnson, Anthony; Gallur, Luis; Shin, Joo; Henderson, Christopher; Williamson, Jonathan.

In: Respirology Case Reports, Vol. 7, No. 1, e00380, 01.01.2019, p. 1-4.

Research output: Contribution to journalArticleResearchpeer-review

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