Abstract
Asbestosis is diagnosed with a combination of historical, clinical and radiological findings in the absence of another cause. Histology is required when uncertainty exists, with lung biopsy via VATs being gold standard. Transbronchial cryobiopsy is becoming increasingly popular for diagnosing interstitial lung disease and may provide sufficient lung sample to demonstrate asbestosis. A 73 year old man presented with dyspnoea on a background of rheumatoid arthritis, previous methotrexate use and asbestos exposure. Examination revealed fine crackles in the mid and lower zones bilaterally without signs of pulmonary hypertension. The presence of pleural plaques and basal interstitial reticulation on HRCT was suggestive of asbestosis but histology was required to differentiate this from rheumatoid or methotrexate associated ILD. Samples of lung tissue were obtained via transbronchial cryobiopsy, demonstrating fibrosis and asbestos fibres consistent with asbestosis. Transbronchial cryobiopsy appears effective in obtaining sufficient parenchymal lung samples to diagnose asbestosis when clinical uncertainty exists.
| Language | English |
|---|---|
| Article number | e00380 |
| Pages | 1-4 |
| Number of pages | 4 |
| Journal | Respirology Case Reports |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
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Bibliographical note
Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.Keywords
- Asbestos fibre count
- asbestosis
- cryobiopsy
Cite this
}
Transbronchial lung cryobiopsy : a novel confirmatory tool to diagnose asbestos-related pulmonary fibrosis. / Zajaczkowska, Marta; Johnson, Anthony; Gallur, Luis; Shin, Joo; Henderson, Christopher; Williamson, Jonathan.
In: Respirology Case Reports, Vol. 7, No. 1, e00380, 01.01.2019, p. 1-4.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Transbronchial lung cryobiopsy
T2 - Respirology Case Reports
AU - Zajaczkowska, Marta
AU - Johnson, Anthony
AU - Gallur, Luis
AU - Shin, Joo
AU - Henderson, Christopher
AU - Williamson, Jonathan
N1 - Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Asbestosis is diagnosed with a combination of historical, clinical and radiological findings in the absence of another cause. Histology is required when uncertainty exists, with lung biopsy via VATs being gold standard. Transbronchial cryobiopsy is becoming increasingly popular for diagnosing interstitial lung disease and may provide sufficient lung sample to demonstrate asbestosis. A 73 year old man presented with dyspnoea on a background of rheumatoid arthritis, previous methotrexate use and asbestos exposure. Examination revealed fine crackles in the mid and lower zones bilaterally without signs of pulmonary hypertension. The presence of pleural plaques and basal interstitial reticulation on HRCT was suggestive of asbestosis but histology was required to differentiate this from rheumatoid or methotrexate associated ILD. Samples of lung tissue were obtained via transbronchial cryobiopsy, demonstrating fibrosis and asbestos fibres consistent with asbestosis. Transbronchial cryobiopsy appears effective in obtaining sufficient parenchymal lung samples to diagnose asbestosis when clinical uncertainty exists.
AB - Asbestosis is diagnosed with a combination of historical, clinical and radiological findings in the absence of another cause. Histology is required when uncertainty exists, with lung biopsy via VATs being gold standard. Transbronchial cryobiopsy is becoming increasingly popular for diagnosing interstitial lung disease and may provide sufficient lung sample to demonstrate asbestosis. A 73 year old man presented with dyspnoea on a background of rheumatoid arthritis, previous methotrexate use and asbestos exposure. Examination revealed fine crackles in the mid and lower zones bilaterally without signs of pulmonary hypertension. The presence of pleural plaques and basal interstitial reticulation on HRCT was suggestive of asbestosis but histology was required to differentiate this from rheumatoid or methotrexate associated ILD. Samples of lung tissue were obtained via transbronchial cryobiopsy, demonstrating fibrosis and asbestos fibres consistent with asbestosis. Transbronchial cryobiopsy appears effective in obtaining sufficient parenchymal lung samples to diagnose asbestosis when clinical uncertainty exists.
KW - Asbestos fibre count
KW - asbestosis
KW - cryobiopsy
UR - http://www.scopus.com/inward/record.url?scp=85057441315&partnerID=8YFLogxK
U2 - 10.1002/rcr2.380
DO - 10.1002/rcr2.380
M3 - Article
VL - 7
SP - 1
EP - 4
JO - Respirology Case Reports
JF - Respirology Case Reports
SN - 2051-3380
IS - 1
M1 - e00380
ER -