Transforming growth factor-β, MAPK and Wnt signaling interactions in colorectal cancer

Harish R. Cheruku, Abidali Mohamedali, David I. Cantor, Sock Hwee Tan, Edouard C. Nice, Mark S. Baker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)
348 Downloads (Pure)

Abstract

In non-cancerous cells, transforming growth factor-β (TGFβ) regulates cellular responses primarily through Smad signaling. However, during cancer progression (including colorectal) TGFβ promotes tumoral growth via Smad-independent mechanisms and is involved in crosstalk with various pathways like the mitogen-activated protein kinases (MAPK) and Wnt. Crosstalk between these pathways following activation by TGFβ and subsequent downstream signaling activity can be referred to as a crosstalk signaling signature. This review highlights the progress in understanding TGFβ signaling crosstalk involving various MAPK pathway members (e.g., extracellular signal-regulated kinase (Erk) 1/2, Ras, c-Jun N-terminal kinases (JNK) and p38) and the Wnt signaling pathway.

Original languageEnglish
Pages (from-to)104-115
Number of pages12
JournalEuPA Open Proteomics
Volume8
DOIs
Publication statusPublished - 1 Sep 2015

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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