Transforming growth factor-β1 polymorphisms in patients with brucellosis: An association between codon 10 and 25 polymorphisms and brucellosis

A. Rafiei; M. Hajilooi; R. J. Shakib; S. A. Alavi

doi:10.1111/j.1469-0691.2006.01575.x

Transforming growth factor-β1 polymorphisms in patients with brucellosis: An association between codon 10 and 25 polymorphisms and brucellosis

A. Rafiei^*, M. Hajilooi, R. J. Shakib, S. A. Alavi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

This study examined the association between transforming growth factor (TGF)-β1 polymorphisms and brucellosis. The TGF-β1 genotypes at codons 10 and 25 were determined by an amplification refractory mutation system-PCR among 425 brucellosis patients and 213 healthy volunteers. The frequencies of TGF-β1 codons 10C and 25G were significantly higher among patients than among controls, as was that of TGF-β1 codon 10C/C. The high-producer haplotype (CG/TG) was more frequent among patients than among controls. The findings suggest that genetic polymorphism in codons 10 and 25 of the TGF-β1 gene might contribute to the development of brucellosis.

Original language	English
Pages (from-to)	97-100
Number of pages	4
Journal	Clinical Microbiology and Infection
Volume	13
Issue number	1
DOIs	https://doi.org/10.1111/j.1469-0691.2006.01575.x
Publication status	Published - Jan 2007
Externally published	Yes

Keywords

Brucellosis
Cytokine
Gene polymorphism
Haplotypes
Risk-factor
TGF-β1

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10.1111/j.1469-0691.2006.01575.x

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title = "Transforming growth factor-β1 polymorphisms in patients with brucellosis: An association between codon 10 and 25 polymorphisms and brucellosis",

abstract = "This study examined the association between transforming growth factor (TGF)-β1 polymorphisms and brucellosis. The TGF-β1 genotypes at codons 10 and 25 were determined by an amplification refractory mutation system-PCR among 425 brucellosis patients and 213 healthy volunteers. The frequencies of TGF-β1 codons 10C and 25G were significantly higher among patients than among controls, as was that of TGF-β1 codon 10C/C. The high-producer haplotype (CG/TG) was more frequent among patients than among controls. The findings suggest that genetic polymorphism in codons 10 and 25 of the TGF-β1 gene might contribute to the development of brucellosis.",

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author = "A. Rafiei and M. Hajilooi and Shakib, {R. J.} and Alavi, {S. A.}",

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T1 - Transforming growth factor-β1 polymorphisms in patients with brucellosis

T2 - An association between codon 10 and 25 polymorphisms and brucellosis

AU - Rafiei, A.

AU - Hajilooi, M.

AU - Shakib, R. J.

AU - Alavi, S. A.

PY - 2007/1

Y1 - 2007/1

N2 - This study examined the association between transforming growth factor (TGF)-β1 polymorphisms and brucellosis. The TGF-β1 genotypes at codons 10 and 25 were determined by an amplification refractory mutation system-PCR among 425 brucellosis patients and 213 healthy volunteers. The frequencies of TGF-β1 codons 10C and 25G were significantly higher among patients than among controls, as was that of TGF-β1 codon 10C/C. The high-producer haplotype (CG/TG) was more frequent among patients than among controls. The findings suggest that genetic polymorphism in codons 10 and 25 of the TGF-β1 gene might contribute to the development of brucellosis.

AB - This study examined the association between transforming growth factor (TGF)-β1 polymorphisms and brucellosis. The TGF-β1 genotypes at codons 10 and 25 were determined by an amplification refractory mutation system-PCR among 425 brucellosis patients and 213 healthy volunteers. The frequencies of TGF-β1 codons 10C and 25G were significantly higher among patients than among controls, as was that of TGF-β1 codon 10C/C. The high-producer haplotype (CG/TG) was more frequent among patients than among controls. The findings suggest that genetic polymorphism in codons 10 and 25 of the TGF-β1 gene might contribute to the development of brucellosis.

KW - Brucellosis

KW - Cytokine

KW - Gene polymorphism

KW - Haplotypes

KW - Risk-factor

KW - TGF-β1

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DO - 10.1111/j.1469-0691.2006.01575.x

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AN - SCOPUS:33845312684

SN - 1198-743X

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Transforming growth factor-β1 polymorphisms in patients with brucellosis: An association between codon 10 and 25 polymorphisms and brucellosis

Abstract

Keywords

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