Transforming growth factor-β1 polymorphisms in patients with brucellosis: An association between codon 10 and 25 polymorphisms and brucellosis

A. Rafiei*, M. Hajilooi, R. J. Shakib, S. A. Alavi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

This study examined the association between transforming growth factor (TGF)-β1 polymorphisms and brucellosis. The TGF-β1 genotypes at codons 10 and 25 were determined by an amplification refractory mutation system-PCR among 425 brucellosis patients and 213 healthy volunteers. The frequencies of TGF-β1 codons 10C and 25G were significantly higher among patients than among controls, as was that of TGF-β1 codon 10C/C. The high-producer haplotype (CG/TG) was more frequent among patients than among controls. The findings suggest that genetic polymorphism in codons 10 and 25 of the TGF-β1 gene might contribute to the development of brucellosis.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalClinical Microbiology and Infection
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

Keywords

  • Brucellosis
  • Cytokine
  • Gene polymorphism
  • Haplotypes
  • Risk-factor
  • TGF-β1

Fingerprint

Dive into the research topics of 'Transforming growth factor-β1 polymorphisms in patients with brucellosis: An association between codon 10 and 25 polymorphisms and brucellosis'. Together they form a unique fingerprint.

Cite this