Transmembrane helix 12 of the Staphylococcus aureus multidrug transporter QacA lines the bivalent cationic drug binding pocket

Karl A. Hassan, Ronald A. Skurray, Melissa H. Brown*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

An acidic residue in transmembrane segment (TMS) 10 is important for recognition of bivalent cationic substrates by the QacA multidrug transporter. Remarkably, an acidic residue in TMS 12 compensated for the absence of such a residue in TMS 10, suggesting that TMS 12 is a component of the bivalent cation-binding region.

Original languageEnglish
Pages (from-to)9131-9135
Number of pages5
JournalJournal of Bacteriology
Volume189
Issue number24
DOIs
Publication statusPublished - Dec 2007
Externally publishedYes

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