Transport of mitochondria during axonogenesis

Vadim N. Dedov*, Irina V. Dedova, Patricia J. Armati

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The cellular mechanisms involved in axonogenesis are still unclean In the present work we found that formation of neurites in cultured neonatal dorsal root ganglion neurons co-incided with the redistribution of highly charged mitochondria. Radially distributed in subplasmalemmal space 3 h after plating, highly charged mitochondria formed clusters in the hillocks of predominant neurites during the next 24-48 h and then redistributed into the axons. These results provide evidence that accumulation of a critical mass of charged mitochondria at the site of the future axonal hillock may represent the slow initiation stage of axonogenesis, followed by a fast growth phase.

Original languageEnglish
Pages (from-to)549-552
Number of pages4
JournalIUBMB Life
Volume49
Issue number6
DOIs
Publication statusPublished - Jun 2000
Externally publishedYes

Keywords

  • Axonogenesis
  • Dorsal root ganglion neurons
  • JC-1
  • Mitochondria
  • Mitochondrial membrane potential
  • Neuronal regeneration
  • Plasma membrane

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