Abstract
The cellular mechanisms involved in axonogenesis are still unclean In the present work we found that formation of neurites in cultured neonatal dorsal root ganglion neurons co-incided with the redistribution of highly charged mitochondria. Radially distributed in subplasmalemmal space 3 h after plating, highly charged mitochondria formed clusters in the hillocks of predominant neurites during the next 24-48 h and then redistributed into the axons. These results provide evidence that accumulation of a critical mass of charged mitochondria at the site of the future axonal hillock may represent the slow initiation stage of axonogenesis, followed by a fast growth phase.
Original language | English |
---|---|
Pages (from-to) | 549-552 |
Number of pages | 4 |
Journal | IUBMB Life |
Volume | 49 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2000 |
Externally published | Yes |
Keywords
- Axonogenesis
- Dorsal root ganglion neurons
- JC-1
- Mitochondria
- Mitochondrial membrane potential
- Neuronal regeneration
- Plasma membrane