TY - JOUR
T1 - Traumatic brain injury as a risk factor for Alzheimer's disease
T2 - A review
AU - Lye, Tanya C.
AU - Shores, E. Arthur
PY - 2000
Y1 - 2000
N2 - Accumulating epidemiological evidence implicates traumatic brain injury as a pathogenic agent in the development of Alzheimer's disease (AD). Considering the increase in the prevalence of both traumatic brain injury and AD in recent times, the possibility that brain trauma may provoke the early development of AD has important implications for health service planning, preventative efforts, and medico-legal compensation settlements. This paper evaluates the plausibility of the proposed link between traumatic brain injury and AD, largely by way of exploring a theoretical perspective advanced by Satz (1993) and considering recent contributions from the epidemiological, neuropathological, and biochemical literature that are pertinent to this issue. The literature reviewed provides sufficient support and empirical vindication to give credence to the proposed association between these two neuropsychological entities at the statistical, theoretical, and biological level.
AB - Accumulating epidemiological evidence implicates traumatic brain injury as a pathogenic agent in the development of Alzheimer's disease (AD). Considering the increase in the prevalence of both traumatic brain injury and AD in recent times, the possibility that brain trauma may provoke the early development of AD has important implications for health service planning, preventative efforts, and medico-legal compensation settlements. This paper evaluates the plausibility of the proposed link between traumatic brain injury and AD, largely by way of exploring a theoretical perspective advanced by Satz (1993) and considering recent contributions from the epidemiological, neuropathological, and biochemical literature that are pertinent to this issue. The literature reviewed provides sufficient support and empirical vindication to give credence to the proposed association between these two neuropsychological entities at the statistical, theoretical, and biological level.
UR - http://www.scopus.com/inward/record.url?scp=0033913011&partnerID=8YFLogxK
U2 - 10.1023/A:1009068804787
DO - 10.1023/A:1009068804787
M3 - Review article
C2 - 10937919
AN - SCOPUS:0033913011
VL - 10
SP - 115
EP - 129
JO - Neuropsychology Review
JF - Neuropsychology Review
SN - 1040-7308
IS - 2
ER -