Treatment of chronic airway diseases using nutraceuticals: mechanistic insight

Venkata Sita Rama Raju Allam, Dinesh Kumar Chellappan, Niraj Kumar Jha, Madhur D. Shastri, Gaurav Gupta, Shakti D. Shukla, Sachin K. Singh, Krishna Sunkara, Nitin Chitranshi, Vivek Gupta, Peter R. Wich, Ronan MacLoughlin, Brian Gregory George Oliver, Sara Wernersson, Gunnar Pejler, Kamal Dua*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Respiratory diseases, both acute and chronic, are reported to be the leading cause of morbidity and mortality, affecting millions of people globally, leading to high socio-economic burden for the society in the recent decades. Chronic inflammation and decline in lung function are the common symptoms of respiratory diseases. The current treatment strategies revolve around using appropriate anti-inflammatory agents and bronchodilators. A range of anti-inflammatory agents and bronchodilators are currently available in the market; however, the usage of such medications is limited due to the potential for various adverse effects. To cope with this issue, researchers have been exploring various novel, alternative therapeutic strategies that are safe and effective to treat respiratory diseases. Several studies have been reported on the possible links between food and food-derived products in combating various chronic inflammatory diseases. Nutraceuticals are examples of such food-derived products which are gaining much interest in terms of its usage for the well-being and better human health. As a consequence, intensive research is currently aimed at identifying novel nutraceuticals, and there is an emerging notion that nutraceuticals can have a positive impact in various respiratory diseases. In this review, we discuss the efficacy of nutraceuticals in altering the various cellular and molecular mechanisms involved in mitigating the symptoms of respiratory diseases.

Original languageEnglish
Number of pages15
JournalCritical Reviews in Food Science and Nutrition
Early online date12 May 2021
DOIs
Publication statusE-pub ahead of print - 12 May 2021

Keywords

  • antioxidants
  • lung
  • minerals
  • nutraceuticals
  • phytochemicals
  • probiotics
  • respiratory disease
  • vitamins

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