Treatment of Early Glottic cancer with Transoral Laser Microsurgery: An Australian Experience

Navid Ahmadi; Danielle Stone; Murray Stokan; Hedley Coleman; Gillian Heller; Mark Smith; Faruque Riffat; Akshay Kudpaje; Michael Veness; Carsten E. Palme

doi:10.1007/s12070-022-03392-8

Treatment of Early Glottic cancer with Transoral Laser Microsurgery: An Australian Experience

Navid Ahmadi^*, Danielle Stone, Murray Stokan, Hedley Coleman, Gillian Heller, Mark Smith, Faruque Riffat, Akshay Kudpaje, Michael Veness, Carsten E. Palme

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Early laryngeal carcinomas may be treated by transoral laser microsurgery (TLM) or external beam radiotherapy. We review our experience of surgical treatment of laryngeal pre-malignant and malignant lesions over the past 15 years in a high-volume head neck unit.

Methods: A review of a prospective patient database of patients with laryngeal SCC, who were treated with CO₂ TLM between 2004 and 2019 was carried out.

Results: 83 patients with a mean age of 67.7 (SD: 10.6) years underwent primary curative TLM for T1a/b SCC. 5-year overall survival was 93.2% (95%CI 86.9–100%), disease free survival was 86.0% (95%CI 78.1–94.6%), locoregional control was 91.2% (95%CI: 85.1–97.7%) and larynx preservation rate of 95.1% at 5 years.

Conclusion: TLM is an excellent treatment modality for T1 early glottic SCC, with excellent locoregional control and disease-free survival. It is minimally invasive, outpatient-based, and cost-effective procedure preserving upper aerodigestive tract dysfunction for all activities of daily living.

Original language	English
Pages (from-to)	661-667
Number of pages	7
Journal	Indian Journal of Otolaryngology and Head and Neck Surgery
Volume	75
Issue number	2
DOIs	https://doi.org/10.1007/s12070-022-03392-8
Publication status	Published - Jun 2023
Externally published	Yes

Keywords

Carcinoma, Squamous cell
Laryngeal neoplasms
Laryngoscopy
Laser therapy
Radiotherapy
Survival analysis

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10.1007/s12070-022-03392-8

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title = "Treatment of Early Glottic cancer with Transoral Laser Microsurgery: An Australian Experience",

abstract = "Introduction: Early laryngeal carcinomas may be treated by transoral laser microsurgery (TLM) or external beam radiotherapy. We review our experience of surgical treatment of laryngeal pre-malignant and malignant lesions over the past 15 years in a high-volume head neck unit.Methods: A review of a prospective patient database of patients with laryngeal SCC, who were treated with CO2 TLM between 2004 and 2019 was carried out.Results: 83 patients with a mean age of 67.7 (SD: 10.6) years underwent primary curative TLM for T1a/b SCC. 5-year overall survival was 93.2% (95%CI 86.9–100%), disease free survival was 86.0% (95%CI 78.1–94.6%), locoregional control was 91.2% (95%CI: 85.1–97.7%) and larynx preservation rate of 95.1% at 5 years.Conclusion: TLM is an excellent treatment modality for T1 early glottic SCC, with excellent locoregional control and disease-free survival. It is minimally invasive, outpatient-based, and cost-effective procedure preserving upper aerodigestive tract dysfunction for all activities of daily living.",

keywords = "Carcinoma, Squamous cell, Laryngeal neoplasms, Laryngoscopy, Laser therapy, Radiotherapy, Survival analysis",

author = "Navid Ahmadi and Danielle Stone and Murray Stokan and Hedley Coleman and Gillian Heller and Mark Smith and Faruque Riffat and Akshay Kudpaje and Michael Veness and Palme, {Carsten E.}",

year = "2023",

month = jun,

doi = "10.1007/s12070-022-03392-8",

language = "English",

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}

TY - JOUR

T1 - Treatment of Early Glottic cancer with Transoral Laser Microsurgery

T2 - An Australian Experience

AU - Ahmadi, Navid

AU - Stone, Danielle

AU - Stokan, Murray

AU - Coleman, Hedley

AU - Heller, Gillian

AU - Smith, Mark

AU - Riffat, Faruque

AU - Kudpaje, Akshay

AU - Veness, Michael

AU - Palme, Carsten E.

PY - 2023/6

Y1 - 2023/6

N2 - Introduction: Early laryngeal carcinomas may be treated by transoral laser microsurgery (TLM) or external beam radiotherapy. We review our experience of surgical treatment of laryngeal pre-malignant and malignant lesions over the past 15 years in a high-volume head neck unit.Methods: A review of a prospective patient database of patients with laryngeal SCC, who were treated with CO2 TLM between 2004 and 2019 was carried out.Results: 83 patients with a mean age of 67.7 (SD: 10.6) years underwent primary curative TLM for T1a/b SCC. 5-year overall survival was 93.2% (95%CI 86.9–100%), disease free survival was 86.0% (95%CI 78.1–94.6%), locoregional control was 91.2% (95%CI: 85.1–97.7%) and larynx preservation rate of 95.1% at 5 years.Conclusion: TLM is an excellent treatment modality for T1 early glottic SCC, with excellent locoregional control and disease-free survival. It is minimally invasive, outpatient-based, and cost-effective procedure preserving upper aerodigestive tract dysfunction for all activities of daily living.

AB - Introduction: Early laryngeal carcinomas may be treated by transoral laser microsurgery (TLM) or external beam radiotherapy. We review our experience of surgical treatment of laryngeal pre-malignant and malignant lesions over the past 15 years in a high-volume head neck unit.Methods: A review of a prospective patient database of patients with laryngeal SCC, who were treated with CO2 TLM between 2004 and 2019 was carried out.Results: 83 patients with a mean age of 67.7 (SD: 10.6) years underwent primary curative TLM for T1a/b SCC. 5-year overall survival was 93.2% (95%CI 86.9–100%), disease free survival was 86.0% (95%CI 78.1–94.6%), locoregional control was 91.2% (95%CI: 85.1–97.7%) and larynx preservation rate of 95.1% at 5 years.Conclusion: TLM is an excellent treatment modality for T1 early glottic SCC, with excellent locoregional control and disease-free survival. It is minimally invasive, outpatient-based, and cost-effective procedure preserving upper aerodigestive tract dysfunction for all activities of daily living.

KW - Carcinoma, Squamous cell

KW - Laryngeal neoplasms

KW - Laryngoscopy

KW - Laser therapy

KW - Radiotherapy

KW - Survival analysis

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JF - Indian Journal of Otolaryngology and Head and Neck Surgery

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ER -

Treatment of Early Glottic cancer with Transoral Laser Microsurgery: An Australian Experience

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