Research output per year
Research output per year
Methods of treating a tauopathy in a subject by either administering full length isoform 2 of ρ38γ or its constitutively active mutant ρ38γ D179A. This promotes phosphorylation at threonine in the sequence SSPGSPGTPGSRSR of tau, equivalent to amino acid position threonine 205 (T205) of human tau. The methods also include introducing a phosphomimetic of a phosphorylated tau, wherein the phosphorylated tau has been phosphorylated at threonine in the sequence SSPGSPGTPGSRSR of the tau. The method of treatment results in improving the cognitive ability in a subject suffering from cognitive impairment associated with a tauopathy and reducing tau aggregates and neurofibrillary tangles.
Original language | English |
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Patent number | WO2021056064 |
IPC | C12N 15/ 11 A I,A61P 25/28 2006.1,A61K 38/45 2006.1,A61K 31/7105 2006.1 |
Priority date | 23/09/19 |
Filing date | 23/09/20 |
Publication status | Published - 1 Apr 2021 |
Research output: Patent
Research output: Patent
Research output: Patent