Treatment of tauopathies

Lars Ittner (Inventor), Arne Ittner (Inventor)

Research output: Patent

Abstract

Methods of treating a tauopathy in a subject by either administering full length isoform 2 of ρ38γ or its constitutively active mutant ρ38γ D179A. This promotes phosphorylation at threonine in the sequence SSPGSPGTPGSRSR of tau, equivalent to amino acid position threonine 205 (T205) of human tau. The methods also include introducing a phosphomimetic of a phosphorylated tau, wherein the phosphorylated tau has been phosphorylated at threonine in the sequence SSPGSPGTPGSRSR of the tau. The method of treatment results in improving the cognitive ability in a subject suffering from cognitive impairment associated with a tauopathy and reducing tau aggregates and neurofibrillary tangles.

Original languageEnglish
Patent numberWO2021056064
IPCC12N 15/ 11 A I,A61P 25/28 2006.1,A61K 38/45 2006.1,A61K 31/7105 2006.1
Priority date23/09/19
Filing date23/09/20
Publication statusPublished - 1 Apr 2021

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  • Treatment of tauopathies

    Ittner, L. & Ittner, A., 10 Mar 2022, IPC No. C12N 15/ 11 A I, A61P 25/28, A61K 31/7105, A61K 38/45, Patent No. AU2020353719, 23 Sept 2020, Priority date 23 Sept 2019, Priority No. AU2019903530

    Research output: Patent

    Open Access
  • Treatment of tauopathies

    Ittner, L. & Ittner, A., 27 Oct 2022, IPC No. C07K 14/ 47 A I, A61K 31/713, A61K 39/395, A61K 47/64, A61K 9/28, A61P 25/28, Patent No. US2022339183, Priority date 23 Sept 2019, Priority No. AU2019903530

    Research output: Patent

    Open Access
  • Treatment of tauopathies

    Ittner, L. & Ittner, A., 3 Aug 2022, IPC No. C12N 15/ 11 A I, A61P 25/28, A01K 67/027, A61K 31/7105, A61K 38/45, A61K 48/00, Patent No. EP4034240, Priority date 23 Sept 2019, Priority No. AU2019903530

    Research output: Patent

    Open Access

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