Treatment of tauopathies

Lars Ittner; Arne Ittner

Treatment of tauopathies

Lars Ittner (Inventor), Arne Ittner (Inventor)

Research output: Patent

Abstract

The present invention relates to a method of treating a tauopathy in a subject, a method of improving cognitive ability in a subject suffering from cognitive impairment associated with a tauopathy, a method of reducing tau aggregates and neurofibrillary tangles. The method comprises administering an agent which promotes phosphorylation of tau at threonine in the sequence SSPGSPGTPGSRSR of the tau; and/or introduces a phosphomimetic of a phosphorylated tau, wherein the phosphorylated tau is tau that has been phosphorylated at threonine in the sequence SSPGSPGTPGSRSR of the tau.

Original language	English
Patent number	US2022339183
IPC	C07K 14/ 47 A I,A61K 31/713,A61K 39/395,A61K 47/64,A61K 9/28,A61P 25/28
Priority date	23/09/19
Publication status	Published - 27 Oct 2022

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4 Patent

Treatment of tauopathies
Ittner, L. & Ittner, A., 10 Mar 2022, IPC No. C12N 15/ 11 A I, A61P 25/28, A61K 31/7105, A61K 38/45, Patent No. AU2020353719, 23 Sept 2020, Priority date 23 Sept 2019, Priority No. AU2019903530
Research output: Patent

Open Access
Treatment of tauopathies
Ittner, L. & Ittner, A., 3 Aug 2022, IPC No. C12N 15/ 11 A I, A61P 25/28, A01K 67/027, A61K 31/7105, A61K 38/45, A61K 48/00, Patent No. EP4034240, Priority date 23 Sept 2019, Priority No. AU2019903530
Research output: Patent

Open Access
Treatment of tauopathies
Ittner, L. & Ittner, A., 1 Apr 2021, IPC No. C12N 15/ 11 A I, A61P 25/28 2006.1, A61K 38/45 2006.1, A61K 31/7105 2006.1, Patent No. WO2021056064, 23 Sept 2020, Priority date 23 Sept 2019, Priority No. AU20190903530
Research output: Patent

Open Access

Cite this

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title = "Treatment of tauopathies",

abstract = "The present invention relates to a method of treating a tauopathy in a subject, a method of improving cognitive ability in a subject suffering from cognitive impairment associated with a tauopathy, a method of reducing tau aggregates and neurofibrillary tangles. The method comprises administering an agent which promotes phosphorylation of tau at threonine in the sequence SSPGSPGTPGSRSR of the tau; and/or introduces a phosphomimetic of a phosphorylated tau, wherein the phosphorylated tau is tau that has been phosphorylated at threonine in the sequence SSPGSPGTPGSRSR of the tau.",

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AU - Ittner, Arne

PY - 2022/10/27

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N2 - The present invention relates to a method of treating a tauopathy in a subject, a method of improving cognitive ability in a subject suffering from cognitive impairment associated with a tauopathy, a method of reducing tau aggregates and neurofibrillary tangles. The method comprises administering an agent which promotes phosphorylation of tau at threonine in the sequence SSPGSPGTPGSRSR of the tau; and/or introduces a phosphomimetic of a phosphorylated tau, wherein the phosphorylated tau is tau that has been phosphorylated at threonine in the sequence SSPGSPGTPGSRSR of the tau.

AB - The present invention relates to a method of treating a tauopathy in a subject, a method of improving cognitive ability in a subject suffering from cognitive impairment associated with a tauopathy, a method of reducing tau aggregates and neurofibrillary tangles. The method comprises administering an agent which promotes phosphorylation of tau at threonine in the sequence SSPGSPGTPGSRSR of the tau; and/or introduces a phosphomimetic of a phosphorylated tau, wherein the phosphorylated tau is tau that has been phosphorylated at threonine in the sequence SSPGSPGTPGSRSR of the tau.

M3 - Patent

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Treatment of tauopathies

Abstract

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