Trifunctional organocatalyst-promoted counterion catalysis for fast and enantioselective aza-Morita-Baylis-Hillman reactions at ambient temperature

Jean-Marc Garnier; Fei Liu

doi:10.1039/b901781j

Trifunctional organocatalyst-promoted counterion catalysis for fast and enantioselective aza-Morita-Baylis-Hillman reactions at ambient temperature

Jean-Marc Garnier, Fei Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Fast and enantioselective aza-Morita-Baylis-Hillman reactions between electron-deficient or electron-rich aromatic N-tosyl imines and methyl vinyl ketone were achieved at ambient temperature using asymmetric counterion-directed catalysis promoted by trifunctional organocatalysts with a Brønsted base as the activity switch after protonation with benzoic acid.

Original language	English
Pages (from-to)	1272-1275
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	7
Issue number	7
DOIs	https://doi.org/10.1039/b901781j
Publication status	Published - 2009

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10.1039/b901781j

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title = "Trifunctional organocatalyst-promoted counterion catalysis for fast and enantioselective aza-Morita-Baylis-Hillman reactions at ambient temperature",

abstract = "Fast and enantioselective aza-Morita-Baylis-Hillman reactions between electron-deficient or electron-rich aromatic N-tosyl imines and methyl vinyl ketone were achieved at ambient temperature using asymmetric counterion-directed catalysis promoted by trifunctional organocatalysts with a Br{\o}nsted base as the activity switch after protonation with benzoic acid.",

author = "Jean-Marc Garnier and Fei Liu",

year = "2009",

doi = "10.1039/b901781j",

language = "English",

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journal = "Organic and Biomolecular Chemistry",

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AU - Garnier, Jean-Marc

AU - Liu, Fei

PY - 2009

Y1 - 2009

N2 - Fast and enantioselective aza-Morita-Baylis-Hillman reactions between electron-deficient or electron-rich aromatic N-tosyl imines and methyl vinyl ketone were achieved at ambient temperature using asymmetric counterion-directed catalysis promoted by trifunctional organocatalysts with a Brønsted base as the activity switch after protonation with benzoic acid.

AB - Fast and enantioselective aza-Morita-Baylis-Hillman reactions between electron-deficient or electron-rich aromatic N-tosyl imines and methyl vinyl ketone were achieved at ambient temperature using asymmetric counterion-directed catalysis promoted by trifunctional organocatalysts with a Brønsted base as the activity switch after protonation with benzoic acid.

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U2 - 10.1039/b901781j

DO - 10.1039/b901781j

M3 - Article

C2 - 19300807

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SP - 1272

EP - 1275

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 7

ER -

Trifunctional organocatalyst-promoted counterion catalysis for fast and enantioselective aza-Morita-Baylis-Hillman reactions at ambient temperature

Abstract

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