Trifunctional organocatalyst-promoted counterion catalysis for fast and enantioselective aza-Morita-Baylis-Hillman reactions at ambient temperature

Jean-Marc Garnier, Fei Liu*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    46 Citations (Scopus)

    Abstract

    Fast and enantioselective aza-Morita-Baylis-Hillman reactions between electron-deficient or electron-rich aromatic N-tosyl imines and methyl vinyl ketone were achieved at ambient temperature using asymmetric counterion-directed catalysis promoted by trifunctional organocatalysts with a Brønsted base as the activity switch after protonation with benzoic acid.

    Original languageEnglish
    Pages (from-to)1272-1275
    Number of pages4
    JournalOrganic and Biomolecular Chemistry
    Volume7
    Issue number7
    DOIs
    Publication statusPublished - 2009

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