Tropomyosins in the healthy and diseased nervous system

Merryn Brettle, Shrujna Patel, Thomas Fath*

*Corresponding author for this work

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Regulation of the actin cytoskeleton is dependent on a plethora of actin-associated proteins in all eukaryotic cells. The family of tropomyosins plays a key role in controlling the function of several of these actin-associated proteins and their access to actin filaments. In order to understand the regulation of the actin cytoskeleton in highly dynamic subcellular compartments of neurons such as growth cones of developing neurons and the synaptic compartment of mature neurons, it is pivotal to decipher the functional role of tropomyosins in the nervous system. In this review, we will discuss the current understanding and recent findings on the regulation of the actin cytoskeleton by tropomyosins and potential implication that this has for the dysregulation of the actin cytoskeleton in neurological diseases.

Original languageEnglish
Pages (from-to)311-323
Number of pages13
JournalBrain Research Bulletin
Volume126
DOIs
Publication statusPublished - 1 Sep 2016
Externally publishedYes

Keywords

  • Actin cytoskeleton
  • Central nervous system
  • Neurite outgrowth
  • Regeneration
  • Tropomyosin

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