TY - JOUR
T1 - Tryptophan, neurodegeneration and HIV-associated neurocognitive disorder
AU - Davies, Nicholas W S
AU - Guillemin, Gilles
AU - Brew, Bruce J.
N1 - Copyright the Author(s), publisher and licensee Libertas Academica Ltd. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2010
Y1 - 2010
N2 - This review presents an up-to-date assessment of the role of the tryptophan metabolic and catabolic pathways in neurodegenerative disease and HIV-associated neurocognitive disorder. The kynurenine pathway and the effects of each of its enzymes and products are reviewed. The differential expression of the kynurenine pathway in cells within the brain, including inflammatory cells, is explored given the increasing recognition of the importance of inflammation in neurodegenerative disease. An overview of common mechanisms of neurodegeneration is presented before a review and discussion of the evidence for a pathogenetic role of the kynurenine pathway in Alzheimer's disease, HIV-associated neurocognitive disorder, Huntington's disease, motor neurone disease, and Parkinson's disease.
AB - This review presents an up-to-date assessment of the role of the tryptophan metabolic and catabolic pathways in neurodegenerative disease and HIV-associated neurocognitive disorder. The kynurenine pathway and the effects of each of its enzymes and products are reviewed. The differential expression of the kynurenine pathway in cells within the brain, including inflammatory cells, is explored given the increasing recognition of the importance of inflammation in neurodegenerative disease. An overview of common mechanisms of neurodegeneration is presented before a review and discussion of the evidence for a pathogenetic role of the kynurenine pathway in Alzheimer's disease, HIV-associated neurocognitive disorder, Huntington's disease, motor neurone disease, and Parkinson's disease.
UR - http://www.scopus.com/inward/record.url?scp=84859577726&partnerID=8YFLogxK
M3 - Review article
C2 - 22084594
AN - SCOPUS:84859577726
SN - 1178-6469
VL - 3
SP - 121
EP - 140
JO - International Journal of Tryptophan Research
JF - International Journal of Tryptophan Research
IS - 1
ER -