TY - JOUR
T1 - Tumour location is not an independent prognostic factor for survival following a diagnosis of breast cancer
AU - Jayasinghe, Upali W.
AU - Boyages, John
PY - 2009/2
Y1 - 2009/2
N2 - Previous studies of patients with breast cancer have examined tumour location as a prognostic factor for survival with contradictory results. The current population-based study with 356 women examines the effect of tumour location and other important prognostic factors on survival. Univariate analyses indicated that central location (P < 0.001), a larger pathological tumour size (P = 0.003), number of positive lymph nodes (P < 0.001), younger age at diagnosis (P = 0.003), a more advanced TNM stage (P < 0.001), a higher grade (P = 0.016) and histologic type (P = 0.011) were associated with a higher risk of breast cancer death. The 10-year survival of women with central location was 33%, compared to 73% for medial and 71% for lateral (P < 0.001). However, the differences among tumour locations were markedly reduced after adjustment separately for early (P = 0.39) and advanced (P = 0.56) TNM stages, which also confirmed the results of multivariate analysis that the location does not influence survival after adjustment for other important clinicopathological characteristics.
AB - Previous studies of patients with breast cancer have examined tumour location as a prognostic factor for survival with contradictory results. The current population-based study with 356 women examines the effect of tumour location and other important prognostic factors on survival. Univariate analyses indicated that central location (P < 0.001), a larger pathological tumour size (P = 0.003), number of positive lymph nodes (P < 0.001), younger age at diagnosis (P = 0.003), a more advanced TNM stage (P < 0.001), a higher grade (P = 0.016) and histologic type (P = 0.011) were associated with a higher risk of breast cancer death. The 10-year survival of women with central location was 33%, compared to 73% for medial and 71% for lateral (P < 0.001). However, the differences among tumour locations were markedly reduced after adjustment separately for early (P = 0.39) and advanced (P = 0.56) TNM stages, which also confirmed the results of multivariate analysis that the location does not influence survival after adjustment for other important clinicopathological characteristics.
UR - http://www.scopus.com/inward/record.url?scp=59849104466&partnerID=8YFLogxK
U2 - 10.1016/j.breast.2008.10.004
DO - 10.1016/j.breast.2008.10.004
M3 - Article
C2 - 19028098
AN - SCOPUS:59849104466
SN - 0960-9776
VL - 18
SP - 41
EP - 46
JO - Breast
JF - Breast
IS - 1
ER -