Tuneable manganese oxide nanoparticle based theranostic agents for potential diagnosis and drug delivery

Kingsley Poon, Zufu Lu, Yves De Deene, Yogambha Ramaswamy, Hala Zreiqat*, Gurvinder Singh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Among various magnetic nanoparticles, manganese oxide nanoparticles are considered as established T1 magnetic resonance imaging (MRI) contrast agents for preclinical research. The implications of their degradation properties and use as therapeutic carriers in drug delivery systems have not been explored. In addition, how the chemical composition and size of manganese oxide nanoparticles, as well as the surrounding environment, influence their degradation and MRI contrast properties (T1vs. T2) have not been studied in great detail. A fundamental understanding of their characteristic properties, such as degradation, is highly desirable for developing simultaneous diagnosis and therapeutic solutions. Here, we demonstrate how the precursor type and reaction environment affect the size and chemical composition of manganese oxide nanoparticles and evaluate their influence on the nanoparticle degradability and release of the drug l-3,4-dihydroxyphenylalanine (l-dopa). The results show that the degradation rate (and the associated release of drug l-dopa molecules) of manganese oxide nanoparticles depends on their size, composition and the surrounding environment (aqueous or biometric fluid). The dependence of MRI relaxivities of manganese oxide nanoparticles on the size, chemical composition and nanoparticle degradation in water is also established. A preliminary cell viability study reveals the cytocompatible properties of l-dopa functionalized manganese oxide nanoparticles. Overall, this work provides new insights into smartly designed manganese oxide nanoparticles with multitasking capabilities to target bioimaging and therapeutic applications. This journal is

Original languageEnglish
Pages (from-to)4052-4061
Number of pages10
JournalNanoscale Advances
Volume3
Issue number14
DOIs
Publication statusPublished - 21 Jul 2021

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Copyright the Author(s) 2021. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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