Two-stepping to increase peptide spectra matches in large databases

Mark P. Molloy*

*Corresponding author for this work

Research output: Contribution to journalComment/opinionpeer-review


Metaproteomics and proteogenomic studies face unique challenges in peptide spectra identification due to the very large number of sequences in search databases. Conventional, stringent filtering needed to avoid false positives limits results in these studies due to increasing false negatives, that is, poor sensitivity. Jagtap et al. (Proteomics 2013, 13, 1352-1357) find a solution to this issue by employing a facile two-step search strategy.

Original languageEnglish
Pages (from-to)1229-1230
Number of pages2
Issue number8
Publication statusPublished - Apr 2013

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