Type I Chiari malformation, RBANS performance, and brain morphology

connecting the dots on cognition and macrolevel brain structure

James R. Houston*, Philip A. Allen, Jeffrey M. Rogers, Mei-Ching Lien, Natalie J. Allen, Michelle L. Hughes, Jayapalli Rajiv Bapuraj, Maggie S. Eppelheimer, Francis Loth, Marcus A. Stoodley, Sarel J. Vorster, Mark G. Luciano

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Idiopathic descent of cerebellar tonsils into the cervical spine in Chiari malformation Type I (CMI) is typically associated with occipital headache. Accumulating evidence from experimental studies suggests cognitive effects of CMI. The aim of the current study was to examine the relationship between cognition and CMI using a battery of standardized neuropsychological and symptom inventory instruments. Method: Eighteen untreated adults with CMI, and 18 gender, age, and education matched healthy controls completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and standardized measures of pain, mood, and disability. Morphometric measurements of key neural and osseous elements were also obtained from structural brain magnetic resonance images, for correlation with symptom outcomes. Results: CMI patients exhibited deficits in RBANS attention, immediate memory, delayed memory, and total score. After controlling for pain and associated affective disturbance, the significant group effect for RBANS attention remained. CMI patients also presented seven morphometric differences comprising the cerebellum and posterior cranial fossa compartment that differed from healthy controls, some of which were associated with self-reported pain and disability. Notably, group differences in tonsillar position were associated with self-reported pain, disability, and delayed memory. Conclusion: Adult CMI is associated with domain-specific cognitive change, detectable using a standard clinical instrument. The extent of cognitive impairment is independent of pain or affective symptomatology and may be related to the key pathognomonic feature of the condition.

Original languageEnglish
Pages (from-to)725-738
Number of pages14
JournalNeuropsychology
Volume33
Issue number5
Early online date16 May 2019
DOIs
Publication statusPublished - Jul 2019

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Keywords

  • Brain morphology
  • Chiari malformation
  • Cognitive performance
  • Magnetic resonance imaging

Cite this

Houston, J. R., Allen, P. A., Rogers, J. M., Lien, M-C., Allen, N. J., Hughes, M. L., ... Luciano, M. G. (2019). Type I Chiari malformation, RBANS performance, and brain morphology: connecting the dots on cognition and macrolevel brain structure. Neuropsychology, 33(5), 725-738. https://doi.org/10.1037/neu0000547