UCNP-based photoluminescent nanomedicines for targeted imaging and theranostics of cancer

Evgenii L. Guryev; Anita S. Smyshlyaeva; Natalia Y. Shilyagina; Evgeniya A. Sokolova; Samah Shanwar; Alexey B. Kostyuk; Alexander V. Lyubeshkin; Alexey A. Schulga; Elena V. Konovalova; Quan Lin; Indrajit Roy; Irina V. Balalaeva; Sergey M. Deyev; Andrei V. Zvyagin

doi:10.3390/molecules25184302

UCNP-based photoluminescent nanomedicines for targeted imaging and theranostics of cancer

Evgenii L. Guryev, Anita S. Smyshlyaeva, Natalia Y. Shilyagina, Evgeniya A. Sokolova, Samah Shanwar, Alexey B. Kostyuk, Alexander V. Lyubeshkin, Alexey A. Schulga, Elena V. Konovalova, Quan Lin, Indrajit Roy, Irina V. Balalaeva^*, Sergey M. Deyev, Andrei V. Zvyagin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF₄: Yb,Tm upconversion nanoparticles coated with polyethylene glycol and functionalized with the HER2-specific recombinant targeted toxin DARPin-LoPE. The obtained agents bind to HER2-overexpressing human breast adenocarcinoma cells and demonstrate selective cytotoxicity against this type of cancer cells. Using fluorescent human breast adenocarcinoma xenograft models, the possibility of intravital visualization of the UCNP-based complexes biodistribution and accumulation in tumor was demonstrated.

Original language	English
Article number	4302
Number of pages	13
Journal	Molecules
Volume	25
Issue number	18
DOIs	https://doi.org/10.3390/molecules25184302
Publication status	Published - 1 Sept 2020
Externally published	Yes

Bibliographical note

Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Antigen
Drug
Imaging
Immunoconjugates
Therapy
Tumor

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10.3390/molecules25184302

Publisher version (open access)Final published version, 1.94 MBLicence: CC BY

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Guryev, E. L., Smyshlyaeva, A. S., Shilyagina, N. Y., Sokolova, E. A., Shanwar, S., Kostyuk, A. B., Lyubeshkin, A. V., Schulga, A. A., Konovalova, E. V., Lin, Q., Roy, I., Balalaeva, I. V., Deyev, S. M., & Zvyagin, A. V. (2020). UCNP-based photoluminescent nanomedicines for targeted imaging and theranostics of cancer. Molecules, 25(18), [4302]. https://doi.org/10.3390/molecules25184302

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abstract = "Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF4: Yb,Tm upconversion nanoparticles coated with polyethylene glycol and functionalized with the HER2-specific recombinant targeted toxin DARPin-LoPE. The obtained agents bind to HER2-overexpressing human breast adenocarcinoma cells and demonstrate selective cytotoxicity against this type of cancer cells. Using fluorescent human breast adenocarcinoma xenograft models, the possibility of intravital visualization of the UCNP-based complexes biodistribution and accumulation in tumor was demonstrated.",

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note = "Copyright {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

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AU - Guryev, Evgenii L.

AU - Smyshlyaeva, Anita S.

AU - Shilyagina, Natalia Y.

AU - Sokolova, Evgeniya A.

AU - Shanwar, Samah

AU - Kostyuk, Alexey B.

AU - Lyubeshkin, Alexander V.

AU - Schulga, Alexey A.

AU - Konovalova, Elena V.

AU - Lin, Quan

AU - Roy, Indrajit

AU - Balalaeva, Irina V.

AU - Deyev, Sergey M.

AU - Zvyagin, Andrei V.

N1 - Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF4: Yb,Tm upconversion nanoparticles coated with polyethylene glycol and functionalized with the HER2-specific recombinant targeted toxin DARPin-LoPE. The obtained agents bind to HER2-overexpressing human breast adenocarcinoma cells and demonstrate selective cytotoxicity against this type of cancer cells. Using fluorescent human breast adenocarcinoma xenograft models, the possibility of intravital visualization of the UCNP-based complexes biodistribution and accumulation in tumor was demonstrated.

AB - Theranostic approach is currently among the fastest growing trends in cancer treatment. It implies the creation of multifunctional agents for simultaneous precise diagnosis and targeted impact on tumor cells. A new type of theranostic complexes was created based on NaYF4: Yb,Tm upconversion nanoparticles coated with polyethylene glycol and functionalized with the HER2-specific recombinant targeted toxin DARPin-LoPE. The obtained agents bind to HER2-overexpressing human breast adenocarcinoma cells and demonstrate selective cytotoxicity against this type of cancer cells. Using fluorescent human breast adenocarcinoma xenograft models, the possibility of intravital visualization of the UCNP-based complexes biodistribution and accumulation in tumor was demonstrated.

KW - Antigen

KW - Drug

KW - Imaging

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KW - Therapy

KW - Tumor

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UCNP-based photoluminescent nanomedicines for targeted imaging and theranostics of cancer

Abstract

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Keywords

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