Ufasomes are stable particles surrounded by unsaturated fatty acid membranes

J. M. Gebicki*, M. Hicks

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    290 Citations (Scopus)

    Abstract

    The arrangement of lipid molecules in biological membranes enables them to play both a structural part in providing a matrix for membrane proteins and a functional one, in which they act as a barrier to the free flow of solutes 1. These roles are usually fulfilled by phospholipids arranged in a flat bilayer with the hydrophobic segments of the molecules orientated towards the interior of the bilayer. The importance of this orientation is recognized in studies of model lipid membranes. Much of the knowledge of membrane lipid function has come from work with aqueous dispersions of liposomes, or microscopic phospholipid particles, in which the molecular arrangement is similar to the orientation found in biological structures2.

    Original languageEnglish
    Pages (from-to)232-234
    Number of pages3
    JournalNature
    Volume243
    Issue number5404
    DOIs
    Publication statusPublished - 25 May 1973

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