Ultra-sensitive electrochemical on-line determination of Clarithromycin based on Poly (L-Aspartic Acid)/Graphite Oxide/Pristine Graphene/Glassy Carbon Electrode

Navid Rabiee, Moein Safarkhani, Mohammad Rabiee

Research output: Contribution to journalArticlepeer-review

Abstract

In this work, a novel and extra sensitive method for on-line continues monitoring of Clarithromycin in whole blood sample was introduced based on coupling of electro-membrane extraction (EME) and stripping fast Fourier transform continuous cyclic voltammetry (SFFTCCV). In this method, the potential waveform was continuously applied on a Poly(L-Aspartic Acid)/Graphite Oxide/Pristine Graphene/Glassy Carbon Electrode and the electrode response was obtained by detracting the background current and in the following integrating the current in the specific potential range of oxidation of the analyte. This method was performed by applying a DC potential and migration of Clarithromycin from the sample solution into a layer of 4-methyl-2-pentanol that is immobilized in the pores of the sheet membrane and then migration into the acceptor solution. A low and valuable detection limit of 1.0 ng ml-1 and quantification limit of 6.0 ng ml-1 are considered as a part of the sensible results of this experiment. Furthermore, an efficient linearity in the range of 6.0-1000 ng ml-1 were found.
Original languageEnglish
Pages (from-to)63-73
Number of pages11
JournalAsian Journal of Nanosciences and Materials
Volume1
Issue number2
DOIs
Publication statusPublished - 2018
Externally publishedYes

Keywords

  • Clarithromycin
  • electrochemical
  • on-line determination
  • pristine graphene
  • Poly(L-Aspartic Acid)

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