Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics

Ming Li; Ji Qi; Jianbo Zeng; Fusheng Zhao; Ulrich Strych; Richard C. Willson; Wei-Chuan Shih

Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics

Ming Li, Ji Qi, Jianbo Zeng, Fusheng Zhao, Ulrich Strych, Richard C. Willson, Wei-Chuan Shih

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution

Abstract

We report a novel microfluidic sensing platform enabled by disk-shaped nanoporous gold nanoparticles (NPGNs), representing a unique class of hierarchical plasmonic nanoparticle. NPGNs possess large specific surface area and high-density, internal plasmonic "hot-spots" with impressive electric field enhancement, which greatly promotes plasmon-matter interaction as evidenced by spectral shifts in the surface plasmon resonance. In addition, the plasmonic resonance of disk-shaped NPGNs can be easily tuned from 900 to 1850 nm by changing the disk diameter from 300 to 700 nm. By surface-enhanced Raman scattering, we demonstrate label-free sensing of biomolecules and in situ monitoring of individual DNA hybridization.

Original language	English
Title of host publication	MicroTAS 2014
Place of Publication	San Diego, California
Publisher	CBM Society
Pages	1823-1825
Number of pages	3
ISBN (Print)	9780979806476
Publication status	Published - 2014
Externally published	Yes
Event	The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) - San Antonio, United States Duration: 26 Oct 2014 → 30 Oct 2014 Conference number: 18th

Conference

Conference	The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)
Country/Territory	United States
City	San Antonio
Period	26/10/14 → 30/10/14

Keywords

molecular sensing
label-free
plasmonics
SERS

Cite this

@inproceedings{89a3a15e067d4ab88146d781025f5919,

title = "Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics",

abstract = "We report a novel microfluidic sensing platform enabled by disk-shaped nanoporous gold nanoparticles (NPGNs), representing a unique class of hierarchical plasmonic nanoparticle. NPGNs possess large specific surface area and high-density, internal plasmonic {"}hot-spots{"} with impressive electric field enhancement, which greatly promotes plasmon-matter interaction as evidenced by spectral shifts in the surface plasmon resonance. In addition, the plasmonic resonance of disk-shaped NPGNs can be easily tuned from 900 to 1850 nm by changing the disk diameter from 300 to 700 nm. By surface-enhanced Raman scattering, we demonstrate label-free sensing of biomolecules and in situ monitoring of individual DNA hybridization.",

keywords = "molecular sensing, label-free, plasmonics, SERS",

author = "Ming Li and Ji Qi and Jianbo Zeng and Fusheng Zhao and Ulrich Strych and Willson, \{Richard C.\} and Wei-Chuan Shih",

year = "2014",

language = "English",

isbn = "9780979806476",

pages = "1823--1825",

booktitle = "MicroTAS 2014",

publisher = "CBM Society",

note = "The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) ; Conference date: 26-10-2014 Through 30-10-2014",

}

Li, M, Qi, J, Zeng, J, Zhao, F, Strych, U, Willson, RC & Shih, W-C 2014, Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics. in MicroTAS 2014. CBM Society, San Diego, California, pp. 1823-1825, The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014), San Antonio, Texas, United States, 26/10/14.

TY - GEN

T1 - Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics

AU - Li, Ming

AU - Qi, Ji

AU - Zeng, Jianbo

AU - Zhao, Fusheng

AU - Strych, Ulrich

AU - Willson, Richard C.

AU - Shih, Wei-Chuan

N1 - Conference code: 18th

PY - 2014

Y1 - 2014

N2 - We report a novel microfluidic sensing platform enabled by disk-shaped nanoporous gold nanoparticles (NPGNs), representing a unique class of hierarchical plasmonic nanoparticle. NPGNs possess large specific surface area and high-density, internal plasmonic "hot-spots" with impressive electric field enhancement, which greatly promotes plasmon-matter interaction as evidenced by spectral shifts in the surface plasmon resonance. In addition, the plasmonic resonance of disk-shaped NPGNs can be easily tuned from 900 to 1850 nm by changing the disk diameter from 300 to 700 nm. By surface-enhanced Raman scattering, we demonstrate label-free sensing of biomolecules and in situ monitoring of individual DNA hybridization.

AB - We report a novel microfluidic sensing platform enabled by disk-shaped nanoporous gold nanoparticles (NPGNs), representing a unique class of hierarchical plasmonic nanoparticle. NPGNs possess large specific surface area and high-density, internal plasmonic "hot-spots" with impressive electric field enhancement, which greatly promotes plasmon-matter interaction as evidenced by spectral shifts in the surface plasmon resonance. In addition, the plasmonic resonance of disk-shaped NPGNs can be easily tuned from 900 to 1850 nm by changing the disk diameter from 300 to 700 nm. By surface-enhanced Raman scattering, we demonstrate label-free sensing of biomolecules and in situ monitoring of individual DNA hybridization.

KW - molecular sensing

KW - label-free

KW - plasmonics

KW - SERS

UR - https://www.scopus.com/pages/publications/84941630091

M3 - Conference proceeding contribution

SN - 9780979806476

SP - 1823

EP - 1825

BT - MicroTAS 2014

PB - CBM Society

CY - San Diego, California

T2 - The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)

Y2 - 26 October 2014 through 30 October 2014

ER -

Ultrasensitive label-free biomolecular sensing on disk-shaped nanoporous gold nanoparticles in microfluidics

Abstract

Conference

Keywords

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