Ultrastructural evidence for the stimulation of nuclear ribonucleic acid synthesis by oestradiol-17β in the vaginal epithelium of the ovariectomized mouse

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Abstract

The cytochemical nature of the ultrastructural nucleolar transformation previously observed in the vaginal epithelium of the ovariectomized mouse after local application of oestradiol-17β was investigated using a recently developed ultrastructural staining technique. Oestradiol treatment induced ribonucleic acid (RNA) synthesis, especially in the nucleolus but also in the nuclear chromatic region and ribosomes. Actinomycin D administered simultaneously with oestradiol reduced the oestrogen-induced nucleolar response to the control level. These findings are discussed with special reference to the mode of action of oestrogens.
LanguageEnglish
Pages143-148
Number of pages6
JournalJournal of Endocrinology
Volume47
Issue number2
DOIs
Publication statusPublished - Jun 1970
Externally publishedYes

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Estradiol
Epithelium
RNA
Estrogens
Dactinomycin
Ribosomes
Color
Staining and Labeling

Cite this

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abstract = "The cytochemical nature of the ultrastructural nucleolar transformation previously observed in the vaginal epithelium of the ovariectomized mouse after local application of oestradiol-17β was investigated using a recently developed ultrastructural staining technique. Oestradiol treatment induced ribonucleic acid (RNA) synthesis, especially in the nucleolus but also in the nuclear chromatic region and ribosomes. Actinomycin D administered simultaneously with oestradiol reduced the oestrogen-induced nucleolar response to the control level. These findings are discussed with special reference to the mode of action of oestrogens.",
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