Under pressure: predicting pressurized metered dose inhaler interactions using the atomic force microscope

Paul M. Young; Robert Price; David Lewis; Stephen Edge; Daniela Traini

doi:10.1016/S0021-9797(03)00032-8

Under pressure: predicting pressurized metered dose inhaler interactions using the atomic force microscope

Paul M. Young, Robert Price, David Lewis, Stephen Edge, Daniela Traini

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Drug particulate interactions in pressurized metered dose inhalers (pMDI) may lead to a decrease in aerosolization efficiency and subsequent efficacy in patient treatment. The interactions between salbutamol sulfate (commonly used in Ventolin pMDIs) and a series of pMDI canister materials were investigated using the atomic force microscope (AFM) colloid probe technique. Approximately 4000 individual force–distance curves were determined for a drug probe and three surfaces (10×10 μm areas) in situ, in a model propellant. The area under each force–distance curve was integrated to obtain separation energy values. Median separation energy values followed the rank order borosilicate glass > aluminum > PTFE, suggesting PTFE to be the most suitable canister coating.

Original language	English
Pages (from-to)	298-302
Number of pages	5
Journal	Journal of Colloid and Interface Science
Volume	262
Issue number	1
DOIs	https://doi.org/10.1016/S0021-9797(03)00032-8
Publication status	Published - 1 Jun 2003
Externally published	Yes

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abstract = "Drug particulate interactions in pressurized metered dose inhalers (pMDI) may lead to a decrease in aerosolization efficiency and subsequent efficacy in patient treatment. The interactions between salbutamol sulfate (commonly used in Ventolin pMDIs) and a series of pMDI canister materials were investigated using the atomic force microscope (AFM) colloid probe technique. Approximately 4000 individual force–distance curves were determined for a drug probe and three surfaces (10×10 μm areas) in situ, in a model propellant. The area under each force–distance curve was integrated to obtain separation energy values. Median separation energy values followed the rank order borosilicate glass > aluminum > PTFE, suggesting PTFE to be the most suitable canister coating.",

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AU - Edge, Stephen

AU - Traini, Daniela

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AB - Drug particulate interactions in pressurized metered dose inhalers (pMDI) may lead to a decrease in aerosolization efficiency and subsequent efficacy in patient treatment. The interactions between salbutamol sulfate (commonly used in Ventolin pMDIs) and a series of pMDI canister materials were investigated using the atomic force microscope (AFM) colloid probe technique. Approximately 4000 individual force–distance curves were determined for a drug probe and three surfaces (10×10 μm areas) in situ, in a model propellant. The area under each force–distance curve was integrated to obtain separation energy values. Median separation energy values followed the rank order borosilicate glass > aluminum > PTFE, suggesting PTFE to be the most suitable canister coating.

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Under pressure: predicting pressurized metered dose inhaler interactions using the atomic force microscope

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