Understanding cellular glycan surfaces in the central nervous system

Sameera Iqbal, Mina Ghanimi Fard, Arun Everest-Dass, Nicolle H. Packer, Lindsay M. Parker

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Glycosylation, the enzymatic process by which glycans are attached to proteins and lipids, is the most abundant and functionally important type of post-translational modification associated with brain development, neurodegenerative disorders, psychopathologies and brain cancers. Glycan structures are diverse and complex; however, they have been detected and targeted in the central nervous system (CNS) by various immunohistochemical detection methods using glycan-binding proteins such as anti-glycan antibodies or lectins and/or characterized with analytical techniques such as chromatography and mass spectrometry. The glycan structures on glycoproteins and glycolipids expressed in neural stem cells play key roles in neural development, biological processes and CNS maintenance, such as cell adhesion, signal transduction, molecular trafficking and differentiation. This brief review will highlight some of the important findings on differential glycan expression across stages of CNS cell differentiation and in pathological disorders and diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis, amyotrophic lateral sclerosis, schizophrenia and brain cancer.

LanguageEnglish
Pages89-100
Number of pages12
JournalBiochemical Society Transactions
Volume47
Issue number1
Early online date17 Dec 2018
DOIs
Publication statusPublished - 28 Feb 2019

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Neurology
Polysaccharides
Central Nervous System
Brain
Brain Neoplasms
Glycosylation
Biological Phenomena
Signal transduction
Neural Stem Cells
Glycolipids
Huntington Disease
Cell adhesion
Amyotrophic Lateral Sclerosis
Post Translational Protein Processing
Chromatography
Stem cells
Psychopathology
Lectins
Cell Adhesion
Neurodegenerative Diseases

Cite this

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abstract = "Glycosylation, the enzymatic process by which glycans are attached to proteins and lipids, is the most abundant and functionally important type of post-translational modification associated with brain development, neurodegenerative disorders, psychopathologies and brain cancers. Glycan structures are diverse and complex; however, they have been detected and targeted in the central nervous system (CNS) by various immunohistochemical detection methods using glycan-binding proteins such as anti-glycan antibodies or lectins and/or characterized with analytical techniques such as chromatography and mass spectrometry. The glycan structures on glycoproteins and glycolipids expressed in neural stem cells play key roles in neural development, biological processes and CNS maintenance, such as cell adhesion, signal transduction, molecular trafficking and differentiation. This brief review will highlight some of the important findings on differential glycan expression across stages of CNS cell differentiation and in pathological disorders and diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis, amyotrophic lateral sclerosis, schizophrenia and brain cancer.",
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Understanding cellular glycan surfaces in the central nervous system. / Iqbal, Sameera; Ghanimi Fard, Mina; Everest-Dass, Arun; Packer, Nicolle H.; Parker, Lindsay M.

In: Biochemical Society Transactions, Vol. 47, No. 1, 28.02.2019, p. 89-100.

Research output: Contribution to journalReview articleResearchpeer-review

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