Unexplained sudden death, focussing on genetics and family phenotyping

Hariharan Raju, Elijah R. Behr*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)

Abstract

Purpose of review: Unexplained sudden death and the sudden arrhythmic death syndrome (SADS) affect a small but significant proportion of young and apparently healthy individuals. This review revisits the causes underlying such deaths and the investigational strategies that identify surviving family who may be at risk. Recent findings: Recent epidemiological data is available from case series or government records. The yield from familial cardiological evaluation for inherited conditions has been supported by additional small series. The greatest advance has come with molecular autopsy studies, which have utilized various methodologies and candidate genes to investigate SADS cases and their families. Summary: The latest research replicates and extends the existing knowledge regarding epidemiology and familial evaluation of SADS, whilst genetic studies support a role for the molecular autopsy.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalCurrent Opinion in Cardiology
Volume28
Issue number1
DOIs
Publication statusPublished - 1 Jan 2013
Externally publishedYes

Keywords

  • inherited cardiac conditions
  • molecular autopsy
  • sudden arrhythmic death syndrome
  • sudden unexplained death
  • sudden unexplained death in epilepsy

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