UniCarb-DB: A database resource for glycomic discovery

Catherine A. Hayes, Niclas G. Karlsson, Weston B. Struwe, Frederique Lisacek, Pauline M. Rudd, Nicolle H. Packer, Matthew P. Campbell*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

92 Citations (Scopus)

Abstract

Summary: Glycosylation is one of the most important post-translational modifications of proteins, known to be involved in pathogen recognition, innate immune response and protection of epithelial membranes. However, when compared to the tools and databases available for the processing of high-throughput proteomic data, the glycomic domain is severely lacking. While tools to assist the analysis of mass spectrometry (MS) and HPLC are continuously improving, there are few resources available to support liquid chromatography (LC)-MS/MS techniques for glycan structure profiling. Here, we present a platform for presenting oligosaccharide structures and fragment data characterized by LC-MS/MS strategies. The database is annotated with high-quality datasets and is designed to extend and reinforce those standards and ontologies developed by existing glycomics databases.

Original languageEnglish
Article numberbtr137
Pages (from-to)1343-1344
Number of pages2
JournalBioinformatics
Volume27
Issue number9
DOIs
Publication statusPublished - May 2011

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