UniCarbKB

an emergent knowledge base for glycomics

Matthew P. Campbell, Robyn Peterson, Elisabeth Gasteiger, Julien Mariethoz, Frederique Lisacek, Nicolle H. Packer

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary/reference book

Abstract

Although many international glycobioinformatics activities have tried to address the challenges of developing informatics to support glycomics analysis, the scope of such an endeavor is huge. Glycomics encompasses the analysis of the glycan complement of prokaryotic and eukaryotic cells and includes free oligosaccharides, glycoproteins, glycolipids, proteoglycans, peptidoglycans, and polysaccharides. As a start to the development of such a knowledge base, we have initially focused on capturing information acquired from glycoproteomics analysis. This chapter outlines the current scope of UniCarbKB (www.​unicarbkb.​org) to build a curated knowledge base that captures information on glycan structures and accompanying glycoprotein information, inclusive of information pertinent to global and site-specific glycosylation. Access to high-quality data collections will further the development of innovative glycoprotein analysis tools, which will substantially improve our understanding of the roles of glycans and glycoproteins in systems biology.
Original languageEnglish
Title of host publicationGlycoscience
Subtitle of host publicationbiology and medicine
EditorsTamao Endo, Peter H. Seeberger, Gerald W. Hart, Chi-Huey Wong, Naoyuki Taniguchi
Place of PublicationJapan
PublisherSpringer, Springer Nature
Pages1-7
Number of pages7
ISBN (Print)9784431548362
DOIs
Publication statusPublished - 2014

Keywords

  • Glycomics
  • Glycobiology
  • Glycobioinformatics
  • Database
  • Glycan
  • Glycoproteomics
  • Biocuration

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  • Cite this

    Campbell, M. P., Peterson, R., Gasteiger, E., Mariethoz, J., Lisacek, F., & Packer, N. H. (2014). UniCarbKB: an emergent knowledge base for glycomics. In T. Endo, P. H. Seeberger, G. W. Hart, C-H. Wong, & N. Taniguchi (Eds.), Glycoscience: biology and medicine (pp. 1-7). Japan: Springer, Springer Nature. https://doi.org/10.1007/978-4-431-54836-2_21-1