Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae

Ian T. Paulsen, Marek K. Sliwinski, Bart Nelissen, André Goffeau*, Milton H. Saier

*Corresponding author for this work

Research output: Contribution to journalArticle

189 Citations (Scopus)

Abstract

We present the complete inventory of currently recognized and putative transporters encoded within the genome of Saccharomyces cerevisiae. These 258 transporters are classified into 42 families according to phylogenetic and substrate specificity criteria. Twelve of these yeast families are found only in eukaryotic organisms, and four are so far unique to yeast. Putative yeast-specific families transport heavy metals, arsenite and calcium. The phylogenetic analyses reported allow classification of 139 functionally uncharacterized yeast transporters into families of known functions. The relative proportions of yeast transporters specific for different classes of substrates differ only slightly from those reported for Escherichia coli. However, the ratio of secondary transporters (uniporters, cation symporters and antiporters) to primary ATP-driven transporters is much higher for yeast than for bacteria.

Original languageEnglish
Pages (from-to)116-125
Number of pages10
JournalFEBS Letters
Volume430
Issue number1-2
DOIs
Publication statusPublished - 23 Jun 1998
Externally publishedYes

Keywords

  • Genome analysis
  • Phylogenetic classification
  • Yeast transporter

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