Unmodified hydrated С60 fullerene molecules exhibit antioxidant properties, prevent damage to DNA and proteins induced by reactive oxygen species and protect mice against injuries caused by radiation-induced oxidative stress

Sergey V. Gudkov, Evgenii L. Guryev, Andrei B. Gapeyev, Mars G. Sharapov, Nikolai F. Bunkin, Alexey V. Shkirin, Tatiana S. Zabelina, Alexey P. Glinushkin, Mikhail A. Sevost'yanov, Konstantin N. Belosludtsev, Anatoly V. Chernikov, Vadim I. Bruskov, Andrey V. Zvyagin

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Unmodified hydrated С60 fullerene molecules (C60UHFM) were shown to reduce the formation ROS in water and 8-oxoguanine in DNA upon ionizing radiation impact. C60UHFM efficiently eliminate long-lived protein radicals arising after irradiation. In irradiated mice C60UHFM reduce the rate of single/double-strand DNA breaks and amount of chromosomal breaks. The radioprotective activity of C60UHFM was estimated by the survival rate of animals; the dose modification factor for animal survival was 1.3. Hematological tests showed that C60UHFM injection in mice prior to irradiation results in a decrement of irradiation-induced leucopenia and thrombocytopenia. Histological analysis testified that C60UHFM provide significant protection of small intestine tissues in mice against irradiation-induced damage. The obtained data assume that the radioprotective properties of C60UHFM are determined by their antioxidant, antiradical and DNA-protective qualities. Thus, it was demonstrated that C60UHFM are a novel antioxidant and radioprotective agent capable of substantial reduction of the harmful effects of ionizing radiation.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2019

Keywords

  • Fullerene С₆₀
  • Nanostuctures
  • X-rays
  • Reactive oxygen species
  • DNA damage
  • Radioprotectors
  • Fullerene C

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