Unravelling DPI aerosol performance using in-vitro deposition and particle image velocimetry

Vishal Chaugule; Larissa Gomes dos Reis; David F. Fletcher; Paul M. Young; Daniela Traini; Julio Soria

Unravelling DPI aerosol performance using in-vitro deposition and particle image velocimetry

Vishal Chaugule, Larissa Gomes dos Reis, David F. Fletcher, Paul M. Young, Daniela Traini, Julio Soria

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

Abstract

Despite the growing use of dry powder inhalers (DPIs) to treat pulmonary diseases, there is limited knowledge of the underlying physical mechanisms of aerosol generation and dispersion. The numerous factors governing dry powder inhalation, such as device design, inhalation flow rate, inspiratory pressures, and formulation properties add to the complexity of these mechanisms. In order to understand DPI aerosol performance comprehensively, it is essential to investigate the fluid-dynamic characteristics of the inhalation flow generated from the device, as these are closely related to each other. This investigation is carried out experimentally using particle image velocimetry (PIV), and the results used to explain those from complementary in-vitro deposition experiments. PIV enables measurement of the instantaneous two component–two dimensional
(2C–2D) velocity field with high spatial and temporal resolutions, and thus provides a quantitative description of the real flow characteristics.

Original language	English
Title of host publication	Respiratory Drug Delivery 2021
Editors	R. N. Dalby, J. Peart, J. D. Suman, P. M. Young, D. Traini
Place of Publication	Richmond, VA
Publisher	RDD Online
Pages	203-208
Number of pages	6
Volume	1
ISBN (Electronic)	9781942911555
Publication status	Published - 2021
Externally published	Yes
Event	Respiratory Drug Delivery 2021 - Virtual Duration: 4 May 2021 → 7 May 2021

Conference

Conference	Respiratory Drug Delivery 2021
Abbreviated title	RDD 2021
City	Virtual
Period	4/05/21 → 7/05/21

Keywords

dry powder inhaler (DPI)
particle image velocimetry (PIV)
in-vitro deposition
aerosol performance
swirling flow

Access to Document

https://www.rddonline.com/rdd/article.php?ArticleID=2796&id=20

Cite this

Chaugule, V., Gomes dos Reis, L., Fletcher, D. F., Young, P. M., Traini, D., & Soria, J. (2021). Unravelling DPI aerosol performance using in-vitro deposition and particle image velocimetry. In R. N. Dalby, J. Peart, J. D. Suman, P. M. Young, & D. Traini (Eds.), Respiratory Drug Delivery 2021 (Vol. 1, pp. 203-208). RDD Online. https://www.rddonline.com/rdd/article.php?ArticleID=2796&id=20

@inproceedings{dc89709d15ab4ddcbcf2587494c08e34,

title = "Unravelling DPI aerosol performance using in-vitro deposition and particle image velocimetry",

abstract = "Despite the growing use of dry powder inhalers (DPIs) to treat pulmonary diseases, there is limited knowledge of the underlying physical mechanisms of aerosol generation and dispersion. The numerous factors governing dry powder inhalation, such as device design, inhalation flow rate, inspiratory pressures, and formulation properties add to the complexity of these mechanisms. In order to understand DPI aerosol performance comprehensively, it is essential to investigate the fluid-dynamic characteristics of the inhalation flow generated from the device, as these are closely related to each other. This investigation is carried out experimentally using particle image velocimetry (PIV), and the results used to explain those from complementary in-vitro deposition experiments. PIV enables measurement of the instantaneous two component–two dimensional(2C–2D) velocity field with high spatial and temporal resolutions, and thus provides a quantitative description of the real flow characteristics.",

keywords = "dry powder inhaler (DPI), particle image velocimetry (PIV), in-vitro deposition, aerosol performance, swirling flow",

author = "Vishal Chaugule and {Gomes dos Reis}, Larissa and Fletcher, {David F.} and Young, {Paul M.} and Daniela Traini and Julio Soria",

year = "2021",

language = "English",

volume = "1",

pages = "203--208",

editor = "Dalby, {R. N.} and J. Peart and Suman, {J. D.} and Young, {P. M.} and D. Traini",

booktitle = "Respiratory Drug Delivery 2021",

publisher = "RDD Online",

note = "Respiratory Drug Delivery 2021, RDD 2021 ; Conference date: 04-05-2021 Through 07-05-2021",

}

Chaugule, V, Gomes dos Reis, L, Fletcher, DF, Young, PM , Traini, D & Soria, J 2021, Unravelling DPI aerosol performance using in-vitro deposition and particle image velocimetry. in RN Dalby, J Peart, JD Suman, PM Young & D Traini (eds), Respiratory Drug Delivery 2021. vol. 1, RDD Online, Richmond, VA, pp. 203-208, Respiratory Drug Delivery 2021, Virtual, 4/05/21. <https://www.rddonline.com/rdd/article.php?ArticleID=2796&id=20>

Unravelling DPI aerosol performance using in-vitro deposition and particle image velocimetry. / Chaugule, Vishal; Gomes dos Reis, Larissa; Fletcher, David F. et al.
Respiratory Drug Delivery 2021. ed. / R. N. Dalby; J. Peart; J. D. Suman; P. M. Young; D. Traini. Vol. 1 Richmond, VA: RDD Online, 2021. p. 203-208.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

TY - GEN

T1 - Unravelling DPI aerosol performance using in-vitro deposition and particle image velocimetry

AU - Chaugule, Vishal

AU - Gomes dos Reis, Larissa

AU - Fletcher, David F.

AU - Young, Paul M.

AU - Traini, Daniela

AU - Soria, Julio

PY - 2021

Y1 - 2021

N2 - Despite the growing use of dry powder inhalers (DPIs) to treat pulmonary diseases, there is limited knowledge of the underlying physical mechanisms of aerosol generation and dispersion. The numerous factors governing dry powder inhalation, such as device design, inhalation flow rate, inspiratory pressures, and formulation properties add to the complexity of these mechanisms. In order to understand DPI aerosol performance comprehensively, it is essential to investigate the fluid-dynamic characteristics of the inhalation flow generated from the device, as these are closely related to each other. This investigation is carried out experimentally using particle image velocimetry (PIV), and the results used to explain those from complementary in-vitro deposition experiments. PIV enables measurement of the instantaneous two component–two dimensional(2C–2D) velocity field with high spatial and temporal resolutions, and thus provides a quantitative description of the real flow characteristics.

AB - Despite the growing use of dry powder inhalers (DPIs) to treat pulmonary diseases, there is limited knowledge of the underlying physical mechanisms of aerosol generation and dispersion. The numerous factors governing dry powder inhalation, such as device design, inhalation flow rate, inspiratory pressures, and formulation properties add to the complexity of these mechanisms. In order to understand DPI aerosol performance comprehensively, it is essential to investigate the fluid-dynamic characteristics of the inhalation flow generated from the device, as these are closely related to each other. This investigation is carried out experimentally using particle image velocimetry (PIV), and the results used to explain those from complementary in-vitro deposition experiments. PIV enables measurement of the instantaneous two component–two dimensional(2C–2D) velocity field with high spatial and temporal resolutions, and thus provides a quantitative description of the real flow characteristics.

KW - dry powder inhaler (DPI)

KW - particle image velocimetry (PIV)

KW - in-vitro deposition

KW - aerosol performance

KW - swirling flow

M3 - Conference proceeding contribution

VL - 1

SP - 203

EP - 208

BT - Respiratory Drug Delivery 2021

A2 - Dalby, R. N.

A2 - Peart, J.

A2 - Suman, J. D.

A2 - Young, P. M.

A2 - Traini, D.

PB - RDD Online

CY - Richmond, VA

T2 - Respiratory Drug Delivery 2021

Y2 - 4 May 2021 through 7 May 2021

ER -

Unravelling DPI aerosol performance using in-vitro deposition and particle image velocimetry

Abstract

Conference

Keywords

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