Unravelling DPI aerosol performance using in-vitro deposition and particle image velocimetry

Vishal Chaugule, Larissa Gomes dos Reis, David F. Fletcher, Paul M. Young, Daniela Traini, Julio Soria

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review


Despite the growing use of dry powder inhalers (DPIs) to treat pulmonary diseases, there is limited knowledge of the underlying physical mechanisms of aerosol generation and dispersion. The numerous factors governing dry powder inhalation, such as device design, inhalation flow rate, inspiratory pressures, and formulation properties add to the complexity of these mechanisms. In order to understand DPI aerosol performance comprehensively, it is essential to investigate the fluid-dynamic characteristics of the inhalation flow generated from the device, as these are closely related to each other. This investigation is carried out experimentally using particle image velocimetry (PIV), and the results used to explain those from complementary in-vitro deposition experiments. PIV enables measurement of the instantaneous two component–two dimensional
(2C–2D) velocity field with high spatial and temporal resolutions, and thus provides a quantitative description of the real flow characteristics.
Original languageEnglish
Title of host publicationRespiratory Drug Delivery 2021
EditorsR. N. Dalby, J. Peart, J. D. Suman, P. M. Young, D. Traini
Place of PublicationRichmond, VA
PublisherRDD Online
Number of pages6
ISBN (Electronic)9781942911555
Publication statusPublished - 2021
Externally publishedYes
EventRespiratory Drug Delivery 2021 - Virtual
Duration: 4 May 20217 May 2021


ConferenceRespiratory Drug Delivery 2021
Abbreviated titleRDD 2021


  • dry powder inhaler (DPI)
  • particle image velocimetry (PIV)
  • in-vitro deposition
  • aerosol performance
  • swirling flow


Dive into the research topics of 'Unravelling DPI aerosol performance using in-vitro deposition and particle image velocimetry'. Together they form a unique fingerprint.

Cite this