Unravelling shared mechanisms: insights from recent ME/CFS research to illuminate long COVID pathologies

Sarah J. Annesley; Daniel Missailidis; Benjamin Heng; Elisha Josev; Christopher W. Armstrong

doi:10.1016/j.molmed.2024.02.003

Unravelling shared mechanisms: insights from recent ME/CFS research to illuminate long COVID pathologies

Sarah J. Annesley^*, Daniel Missailidis, Benjamin Heng, Elisha Josev, Christopher W. Armstrong

^*Corresponding author for this work

Macquarie Medical School

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

15 Downloads (Pure)

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic illness often triggered by an initiating acute event, mainly viral infections. The transition from acute to chronic disease remains unknown, but interest in this phenomenon has escalated since the COVID-19 pandemic and the post-COVID-19 illness, termed ‘long COVID’ (LC). Both ME/CFS and LC share many clinical similarities. Here, we present recent findings in ME/CFS research focussing on proposed disease pathologies shared with LC. Understanding these disease pathologies and how they influence each other is key to developing effective therapeutics and diagnostic tests. Given that ME/CFS typically has a longer disease duration compared with LC, with symptoms and pathologies evolving over time, ME/CFS may provide insights into the future progression of LC.

Original language	English
Pages (from-to)	443-458
Number of pages	16
Journal	Trends in Molecular Medicine
Volume	30
Issue number	5
Early online date	4 Mar 2024
DOIs	https://doi.org/10.1016/j.molmed.2024.02.003
Publication status	Published - May 2024

Bibliographical note

Copyright the Author(s) 2024. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

biomarkers
immune system
long COVID (LC)
ME/CFS
metabolic dysfunction
neuroinflammation

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10.1016/j.molmed.2024.02.003Licence: CC BY-NC

Publisher version (open access)Final published version, 1.8 MBLicence: CC BY-NC

Cite this

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title = "Unravelling shared mechanisms: insights from recent ME/CFS research to illuminate long COVID pathologies",

abstract = "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic illness often triggered by an initiating acute event, mainly viral infections. The transition from acute to chronic disease remains unknown, but interest in this phenomenon has escalated since the COVID-19 pandemic and the post-COVID-19 illness, termed {\textquoteleft}long COVID{\textquoteright} (LC). Both ME/CFS and LC share many clinical similarities. Here, we present recent findings in ME/CFS research focussing on proposed disease pathologies shared with LC. Understanding these disease pathologies and how they influence each other is key to developing effective therapeutics and diagnostic tests. Given that ME/CFS typically has a longer disease duration compared with LC, with symptoms and pathologies evolving over time, ME/CFS may provide insights into the future progression of LC.",

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author = "Annesley, {Sarah J.} and Daniel Missailidis and Benjamin Heng and Elisha Josev and Armstrong, {Christopher W.}",

note = "Copyright the Author(s) 2024. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2024",

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doi = "10.1016/j.molmed.2024.02.003",

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AU - Annesley, Sarah J.

AU - Missailidis, Daniel

AU - Heng, Benjamin

AU - Josev, Elisha

AU - Armstrong, Christopher W.

N1 - Copyright the Author(s) 2024. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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N2 - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic illness often triggered by an initiating acute event, mainly viral infections. The transition from acute to chronic disease remains unknown, but interest in this phenomenon has escalated since the COVID-19 pandemic and the post-COVID-19 illness, termed ‘long COVID’ (LC). Both ME/CFS and LC share many clinical similarities. Here, we present recent findings in ME/CFS research focussing on proposed disease pathologies shared with LC. Understanding these disease pathologies and how they influence each other is key to developing effective therapeutics and diagnostic tests. Given that ME/CFS typically has a longer disease duration compared with LC, with symptoms and pathologies evolving over time, ME/CFS may provide insights into the future progression of LC.

AB - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic illness often triggered by an initiating acute event, mainly viral infections. The transition from acute to chronic disease remains unknown, but interest in this phenomenon has escalated since the COVID-19 pandemic and the post-COVID-19 illness, termed ‘long COVID’ (LC). Both ME/CFS and LC share many clinical similarities. Here, we present recent findings in ME/CFS research focussing on proposed disease pathologies shared with LC. Understanding these disease pathologies and how they influence each other is key to developing effective therapeutics and diagnostic tests. Given that ME/CFS typically has a longer disease duration compared with LC, with symptoms and pathologies evolving over time, ME/CFS may provide insights into the future progression of LC.

KW - biomarkers

KW - immune system

KW - long COVID (LC)

KW - ME/CFS

KW - metabolic dysfunction

KW - neuroinflammation

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DO - 10.1016/j.molmed.2024.02.003

M3 - Review article

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SP - 443

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JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

IS - 5

ER -

Unravelling shared mechanisms: insights from recent ME/CFS research to illuminate long COVID pathologies

Abstract

Bibliographical note

Keywords

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