Upconversion nanoparticles: on the way from diagnostics to theranostics

Alla Generalova; Kristina Mironova; Natalya Sholina; Vasylina Rocheva; Andrey Nechaev; Ekaterina Grebenik; Anna Guller; Andrey Zvyagin; Sergey Deyev; Vitaly Zubov; Evgeny Khaydukov

doi:10.1051/epjconf/201819003001

Upconversion nanoparticles: on the way from diagnostics to theranostics

Alla Generalova^*, Kristina Mironova, Natalya Sholina, Vasylina Rocheva, Andrey Nechaev, Ekaterina Grebenik, Anna Guller, Andrey Zvyagin, Sergey Deyev, Vitaly Zubov, Evgeny Khaydukov

^*Corresponding author for this work

Research output: Contribution to journal › Conference paper › peer-review

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Abstract

We report of surface modification approaches of nanoparticles with anti-Stokes luminescence, known as upconversion nanoparicles (UCNPs), comprised of inorganic host NaYF₄ codoped with Yb³⁺ and Er³⁺or Tm³⁺. These approaches enabled the facile, lossless preparation of hybrid polymer-encapsulated UCNPs suitable for bioassays. These probes inherited UCNP properties, such as excellent photoluminescence under excitation with NIR light from the biotissue "transparency window", as well as they were dispersible in aqueous media and physiological buffers, exhibiting chemical stability. The feasibility of the hybrid UCNPs was demonstrated for in vitro bioassay and in vivo optical whole animal imaging using a home-built epiluminescence imaging system.

Original language	English
Article number	03001
Number of pages	2
Journal	EPJ Web of conferences
Volume	190
DOIs	https://doi.org/10.1051/epjconf/201819003001
Publication status	Published - 26 Sept 2018
Event	13th International Conference on Hole Burning, Single Molecule, and Related Spectroscopies: Science and Applications, HBSM 2018 - Moscow, Russian Federation Duration: 6 Aug 2018 → 12 Aug 2018

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Copyright The Authors, published by EDP Sciences, 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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title = "Upconversion nanoparticles: on the way from diagnostics to theranostics",

abstract = "We report of surface modification approaches of nanoparticles with anti-Stokes luminescence, known as upconversion nanoparicles (UCNPs), comprised of inorganic host NaYF4 codoped with Yb3+ and Er3+or Tm3+. These approaches enabled the facile, lossless preparation of hybrid polymer-encapsulated UCNPs suitable for bioassays. These probes inherited UCNP properties, such as excellent photoluminescence under excitation with NIR light from the biotissue {"}transparency window{"}, as well as they were dispersible in aqueous media and physiological buffers, exhibiting chemical stability. The feasibility of the hybrid UCNPs was demonstrated for in vitro bioassay and in vivo optical whole animal imaging using a home-built epiluminescence imaging system.",

author = "Alla Generalova and Kristina Mironova and Natalya Sholina and Vasylina Rocheva and Andrey Nechaev and Ekaterina Grebenik and Anna Guller and Andrey Zvyagin and Sergey Deyev and Vitaly Zubov and Evgeny Khaydukov",

note = "Copyright The Authors, published by EDP Sciences, 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.; 13th International Conference on Hole Burning, Single Molecule, and Related Spectroscopies: Science and Applications, HBSM 2018 ; Conference date: 06-08-2018 Through 12-08-2018",

year = "2018",

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doi = "10.1051/epjconf/201819003001",

language = "English",

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T2 - 13th International Conference on Hole Burning, Single Molecule, and Related Spectroscopies: Science and Applications, HBSM 2018

AU - Generalova, Alla

AU - Mironova, Kristina

AU - Sholina, Natalya

AU - Rocheva, Vasylina

AU - Nechaev, Andrey

AU - Grebenik, Ekaterina

AU - Guller, Anna

AU - Zvyagin, Andrey

AU - Deyev, Sergey

AU - Zubov, Vitaly

AU - Khaydukov, Evgeny

N1 - Copyright The Authors, published by EDP Sciences, 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2018/9/26

Y1 - 2018/9/26

N2 - We report of surface modification approaches of nanoparticles with anti-Stokes luminescence, known as upconversion nanoparicles (UCNPs), comprised of inorganic host NaYF4 codoped with Yb3+ and Er3+or Tm3+. These approaches enabled the facile, lossless preparation of hybrid polymer-encapsulated UCNPs suitable for bioassays. These probes inherited UCNP properties, such as excellent photoluminescence under excitation with NIR light from the biotissue "transparency window", as well as they were dispersible in aqueous media and physiological buffers, exhibiting chemical stability. The feasibility of the hybrid UCNPs was demonstrated for in vitro bioassay and in vivo optical whole animal imaging using a home-built epiluminescence imaging system.

AB - We report of surface modification approaches of nanoparticles with anti-Stokes luminescence, known as upconversion nanoparicles (UCNPs), comprised of inorganic host NaYF4 codoped with Yb3+ and Er3+or Tm3+. These approaches enabled the facile, lossless preparation of hybrid polymer-encapsulated UCNPs suitable for bioassays. These probes inherited UCNP properties, such as excellent photoluminescence under excitation with NIR light from the biotissue "transparency window", as well as they were dispersible in aqueous media and physiological buffers, exhibiting chemical stability. The feasibility of the hybrid UCNPs was demonstrated for in vitro bioassay and in vivo optical whole animal imaging using a home-built epiluminescence imaging system.

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DO - 10.1051/epjconf/201819003001

M3 - Conference paper

AN - SCOPUS:85054990067

SN - 2101-6275

VL - 190

JO - EPJ Web of conferences

JF - EPJ Web of conferences

M1 - 03001

Y2 - 6 August 2018 through 12 August 2018

ER -

Upconversion nanoparticles: on the way from diagnostics to theranostics

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