Upconversion nanoparticles

on the way from diagnostics to theranostics

Alla Generalova*, Kristina Mironova, Natalya Sholina, Vasylina Rocheva, Andrey Nechaev, Ekaterina Grebenik, Anna Guller, Andrey Zvyagin, Sergey Deyev, Vitaly Zubov, Evgeny Khaydukov

*Corresponding author for this work

Research output: Contribution to journalConference paper

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Abstract

We report of surface modification approaches of nanoparticles with anti-Stokes luminescence, known as upconversion nanoparicles (UCNPs), comprised of inorganic host NaYF4 codoped with Yb3+ and Er3+or Tm3+. These approaches enabled the facile, lossless preparation of hybrid polymer-encapsulated UCNPs suitable for bioassays. These probes inherited UCNP properties, such as excellent photoluminescence under excitation with NIR light from the biotissue "transparency window", as well as they were dispersible in aqueous media and physiological buffers, exhibiting chemical stability. The feasibility of the hybrid UCNPs was demonstrated for in vitro bioassay and in vivo optical whole animal imaging using a home-built epiluminescence imaging system.

Original languageEnglish
Article number03001
Number of pages2
JournalEPJ Web of conferences
Volume190
DOIs
Publication statusPublished - 26 Sep 2018
Event13th International Conference on Hole Burning, Single Molecule, and Related Spectroscopies: Science and Applications, HBSM 2018 - Moscow, Russian Federation
Duration: 6 Aug 201812 Aug 2018

Bibliographical note

Copyright The Authors, published by EDP Sciences, 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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    Generalova, A., Mironova, K., Sholina, N., Rocheva, V., Nechaev, A., Grebenik, E., ... Khaydukov, E. (2018). Upconversion nanoparticles: on the way from diagnostics to theranostics. EPJ Web of conferences, 190, [03001]. https://doi.org/10.1051/epjconf/201819003001