Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts

Nady Braidy, Wei Ping Gai, Ying H. Xu, Perminder Sachdev, Gilles J. Guillemin, Xing Mai Jiang, J. William O Ballard, Martin P. Horan, Zhi M. Fang, Beng H. Chong, Daniel Kam Y Chan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)
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Abstract

The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson's disease (PD). In this study, we show that α-syn can be taken up by primary human cortical neurons, astrocytes and skin-derived fibroblasts in vitro. Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function, leading to cellular degeneration and cell death, provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells.

Original languageEnglish
Article number20
Pages (from-to)1-9
Number of pages9
JournalTranslational Neurodegeneration
Volume2
DOIs
Publication statusPublished - 4 Oct 2013
Externally publishedYes

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