@article{421e492a83664cc8b560c2d5e70f4957,
title = "Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts",
abstract = "The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson's disease (PD). In this study, we show that α-syn can be taken up by primary human cortical neurons, astrocytes and skin-derived fibroblasts in vitro. Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function, leading to cellular degeneration and cell death, provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells.",
author = "Nady Braidy and Gai, {Wei Ping} and Xu, {Ying H.} and Perminder Sachdev and Guillemin, {Gilles J.} and Jiang, {Xing Mai} and Ballard, {J. William O} and Horan, {Martin P.} and Fang, {Zhi M.} and Chong, {Beng H.} and Chan, {Daniel Kam Y}",
note = "This version is archived for private and non-commercial use under the terms of this BioMed Central open access license ({"}license{"}) (see http://www.biomedcentral.com/about/license). The work is protected by copyright and/or other applicable law. Any use of the work other than as authorized under this license is prohibited. For further rights please check the terms of the license, or contact the publisher.",
year = "2013",
month = oct,
day = "4",
doi = "10.1186/2047-9158-2-20",
language = "English",
volume = "2",
pages = "1--9",
journal = "Translational Neurodegeneration",
issn = "2047-9158",
publisher = "Springer, Springer Nature",
}