Urokinase receptor genotypes in colorectal cancer

M. Kohonen-Corish, J. Young, G. Chenevix-Trench, W. F. Doe

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A previous study has reported a high frequency of rare alleles of the urokinase-type plasminogen activator receptor (uPAR) in a set of 15 colorectal cancer (CRC) cell lines. Our study investigated uPAR gene variation in 92 CRC patients and in tumour DNA from a subset of 69 patients using the PLAUR-IVS3 marker located in an intron of this gene. The overall distribution of the marker alleles in the patients did not differ significantly from a set of 105 controls. A pairwise analysis of individual allele frequencies showed, however, that the common allele 147 was significantly decreased (P = 0.027) and allele 149 was significantly increased (P = 0.033) in the patients. These results may indicate an effect of uPAR gene variation in CRC carcinogenesis and encourages further examination of this marker in an independent series of patients.
Original languageEnglish
Pages (from-to)1149-1151
Number of pages3
JournalCarcinogenesis
Volume19
Issue number6
DOIs
Publication statusPublished - Jun 1998
Externally publishedYes

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