Use of antiepileptic drugs in nontraumatic neurosurgical procedures: Is there any best route and time of administration?

Adrian L. Rabinowicz*, Jorge M. Salvat, Ramon C. Leiguarda, Federico Demonty, Fernando Salvat, Andres Cervio, Facundo Manes, Alberto Lazarowski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We assessed in 15 consecutive patients the best route and time of administration for phenytoin (PHT) prophylaxis in neurosurgical procedures. We also correlated PHT levels in serum and cerebrospinal fluid after oral and parenteral loading doses. The mean PHT level was 13.9 μg/ml in serum and 2.03 μg/ml in cerebrospinal fluid (CSF), with a significant correlation between levels in both compartments (r = 0.73, p <0.01). Mean PHT levels among the different groups were not statistically significant. We conclude that therapeutic levels of PHT in CSF can be achieved independently of the route of administration, as long as accepted loading doses are used.

Original languageEnglish
Pages (from-to)438-441
Number of pages4
JournalClinical Neuropharmacology
Volume20
Issue number5
Publication statusPublished - 1997
Externally publishedYes

Keywords

  • Antiepileptic drugs
  • Neurosurgery
  • Phenytoin
  • Prophylaxis

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