Use of drug-eluting stents in Victorian public hospitals

Bryan P. Yan, Andrew E. Ajani, Stephen J. Duffy, Gishel New, Mark Horrigan, Gregory Szto, Antony Walton, David Eccleston, Jeffery Lefkovits, Alexander Black, Martin Sebastian, Angela L. Brennan, Christopher M. Reid, David J. Clark*, J. Shaw, C. Farrington, R. Gunaratne, A. Broughton, J. Federman, C. KeighleyA. Dart, J. Johns, O. Farouque, L. Oliver, J. Brennan, R. Chan, G. Proimos, T. Dortimer, B. Chan, A. Tonkin, L. Brown, N. Campbell, A. Sahar, K. Charter, G. New, L. Roberts, H. Liew, M. Rowe, N. Cheong, C. Goods, R. Lew, R. Templin, T. Yip, L. Ponnuthrai, M. Rahmen, J. Dyson, T. Duplessis, H. Krum, A. Meehan, P. Loane, L. Curran, F. Groen, V. O'Shea, R. Warren, P. Roy, S. Shetty, Y. L. Lim

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)

    Abstract

    Objective: We aimed to assess the pattern of use of drug-eluting stents (DESs) in patients undergoing percutaneous coronary interventions (PCIs) in Victorian public hospitals. Design, setting and patients: Prospective study comparing the use of one or more DESs versus bare-metal stents (BMSs) only, in consecutive patients undergoing 2428 PCIs with stent implantation from 1 April 2004 to 31 December 2005 at seven Victorian public hospitals. Main outcome measures: Adherence to current Victorian Department of Human Services guidelines which recommend DES use in patients with high-risk features for restenosis (diabetes, small vessels, long lesions, in-stent restenotic lesions, chronic total occlusions and bifurcation lesions). Results: Of the 2428 PCIs performed, at least one DES was implanted in 1101 (45.3%) and BMSs only were implanted in 1327 (54.7%). In 87.7% (966/ 1101) of PCI with DESs, there was at least one criterion for high risk of restenosis. DESs were more likely to be used in patients with diabetes (risk ratio [RR], 2.45; 95% CI, 2.02-2.97), small vessels (RR, 3.35; 95%CI, 2.35-4.76), long lesions (RR, 3.87; 95% CI, 3.23-4.65), in-stent restenotic lesions (RR, 3.98; 95%CI, 2.67-6.06), chronic total occlusions (RR, 1.30; 95% CI, 0.51-2.88) and bifurcation lesions (RR, 2.23; 95%CI, 1.57-3.17). However, 66.2% (1608/2428) of all PCIs were in patients eligible for DESs according to Victorian guidelines, and in 39.9% (642/1608) of these PCIs, a BMS was used. Conclusion: In Victorian public hospitals, DESs have been largely reserved for patients at high risk of restenosis in accordance with Department of Human Services guidelines. However, many patients with high-risk criteria for restenosis did not receive DESs. Greater use of DESs in these patients may improve outcomes by reducing the need for repeat revascularisation.

    Original languageEnglish
    Pages (from-to)363-367
    Number of pages5
    JournalMedical Journal of Australia
    Volume185
    Issue number7
    Publication statusPublished - 2 Oct 2006

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