Abstract
The present invention relates to a method of treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject, comprising treating the subject to: (a) promote phosphorylation of one or more amino acid residues of tau, wherein the phosphorylation of the amino acid residues causes disruption of the tau-dependent signalling complex in neurons of the subject; or (b)introduce a variant of tau that causes disruption of the tau-dependent signalling complex in neurons of the subject. The invention also relates to vectors, compositions and kits for treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject.
| Original language | English |
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| Patent number | EP3423080 |
| IPC | A61P 25/28,A61K 38/17,A61K 38/45,A61P 9/10,A61P 25/08 |
| Priority date | 1/03/16 |
| Publication status | Submitted - 9 Jan 2019 |