Use of phosphorylated tau and p38gamma to treat a neurological condition

Lars Matthias Ittner; Arne Anselm Ittner

Use of phosphorylated tau and p38gamma to treat a neurological condition

Lars Matthias Ittner (Inventor), Arne Anselm Ittner (Inventor)

Research output: Patent

Abstract

The present invention relates to a method of treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject, comprising treating the subject to: (a) promote phosphorylation of one or more amino acid residues of tau, wherein the phosphorylation of the amino acid residues causes disruption of the tau-dependent signalling complex in neurons of the subject; or (b)introduce a variant of tau that causes disruption of the tau-dependent signalling complex in neurons of the subject. The invention also relates to vectors, compositions and kits for treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject.

Original language	English
Patent number	EP3423080
IPC	A61P 25/28,A61K 38/17,A61K 38/45,A61P 9/10,A61P 25/08
Priority date	1/03/16
Publication status	Submitted - 9 Jan 2019

Access to Document

https://patentscope.wipo.int/search/en/detail.jsf?docId=EP235914122

1 Patent

Use of phosphorylated tau and p38gamma to treat a neurological condition
Ittner, L. M. & Ittner, A. A., 16 Feb 2023, IPC No. A61P 25/ 28 A I, A61K 38/45, Patent No. US2023053214, Priority date 12 Sept 2022, Priority No. US202217931229
Research output: Patent

Open Access

Cite this

@misc{0c088f3410cf4de7bc372ccbc230267b,

title = "Use of phosphorylated tau and p38gamma to treat a neurological condition",

abstract = "The present invention relates to a method of treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject, comprising treating the subject to: (a) promote phosphorylation of one or more amino acid residues of tau, wherein the phosphorylation of the amino acid residues causes disruption of the tau-dependent signalling complex in neurons of the subject; or (b)introduce a variant of tau that causes disruption of the tau-dependent signalling complex in neurons of the subject. The invention also relates to vectors, compositions and kits for treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject.",

author = "Ittner, {Lars Matthias} and Ittner, {Arne Anselm}",

year = "2019",

month = jan,

day = "9",

language = "English",

type = "Patent",

note = "EP3423080; A61P 25/28,A61K 38/17,A61K 38/45,A61P 9/10,A61P 25/08",

}

TY - PAT

T1 - Use of phosphorylated tau and p38gamma to treat a neurological condition

AU - Ittner, Lars Matthias

AU - Ittner, Arne Anselm

PY - 2019/1/9

Y1 - 2019/1/9

N2 - The present invention relates to a method of treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject, comprising treating the subject to: (a) promote phosphorylation of one or more amino acid residues of tau, wherein the phosphorylation of the amino acid residues causes disruption of the tau-dependent signalling complex in neurons of the subject; or (b)introduce a variant of tau that causes disruption of the tau-dependent signalling complex in neurons of the subject. The invention also relates to vectors, compositions and kits for treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject.

AB - The present invention relates to a method of treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject, comprising treating the subject to: (a) promote phosphorylation of one or more amino acid residues of tau, wherein the phosphorylation of the amino acid residues causes disruption of the tau-dependent signalling complex in neurons of the subject; or (b)introduce a variant of tau that causes disruption of the tau-dependent signalling complex in neurons of the subject. The invention also relates to vectors, compositions and kits for treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject.

M3 - Patent

M1 - EP3423080

ER -

Use of phosphorylated tau and p38gamma to treat a neurological condition

Abstract

Access to Document

Fingerprint

Research output

Use of phosphorylated tau and p38gamma to treat a neurological condition

Cite this