Abstract
Background: By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications. Methods: A systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed. Results: Five RCTs were identified including a total of 379 patients. Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. There was a trend towards a lower incidence of post-operative complications and prothrombin time (PT), but this did not reach statistical significance. Conclusion: Pre-operative steroids may be associated with a clinically significant benefit in liver resection.
Original language | English |
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Pages (from-to) | 12-19 |
Number of pages | 8 |
Journal | HPB |
Volume | 16 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2014 |
Externally published | Yes |