Use of pre-operative steroids in liver resection: a systematic review and meta-analysis

Arthur J. Richardson; Jerome M. Laurence; Vincent W. T. Lam

doi:10.1111/hpb.12066

Use of pre-operative steroids in liver resection: a systematic review and meta-analysis

Arthur J. Richardson^*, Jerome M. Laurence, Vincent W. T. Lam

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

Abstract

Background: By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications. Methods: A systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed. Results: Five RCTs were identified including a total of 379 patients. Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. There was a trend towards a lower incidence of post-operative complications and prothrombin time (PT), but this did not reach statistical significance. Conclusion: Pre-operative steroids may be associated with a clinically significant benefit in liver resection.

Original language	English
Pages (from-to)	12-19
Number of pages	8
Journal	HPB
Volume	16
Issue number	1
DOIs	https://doi.org/10.1111/hpb.12066
Publication status	Published - 1 Jan 2014
Externally published	Yes

Access to Document

10.1111/hpb.12066

Cite this

@article{e5e3c837e4d84090a6733e5dffa7eb6b,

title = "Use of pre-operative steroids in liver resection: a systematic review and meta-analysis",

abstract = "Background: By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications. Methods: A systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed. Results: Five RCTs were identified including a total of 379 patients. Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. There was a trend towards a lower incidence of post-operative complications and prothrombin time (PT), but this did not reach statistical significance. Conclusion: Pre-operative steroids may be associated with a clinically significant benefit in liver resection.",

author = "Richardson, {Arthur J.} and Laurence, {Jerome M.} and Lam, {Vincent W. T.}",

year = "2014",

month = jan,

day = "1",

doi = "10.1111/hpb.12066",

language = "English",

volume = "16",

pages = "12--19",

journal = "HPB",

issn = "1365-182X",

publisher = "John Wiley & Sons",

number = "1",

}

TY - JOUR

T1 - Use of pre-operative steroids in liver resection

T2 - a systematic review and meta-analysis

AU - Richardson, Arthur J.

AU - Laurence, Jerome M.

AU - Lam, Vincent W. T.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications. Methods: A systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed. Results: Five RCTs were identified including a total of 379 patients. Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. There was a trend towards a lower incidence of post-operative complications and prothrombin time (PT), but this did not reach statistical significance. Conclusion: Pre-operative steroids may be associated with a clinically significant benefit in liver resection.

AB - Background: By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications. Methods: A systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed. Results: Five RCTs were identified including a total of 379 patients. Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. There was a trend towards a lower incidence of post-operative complications and prothrombin time (PT), but this did not reach statistical significance. Conclusion: Pre-operative steroids may be associated with a clinically significant benefit in liver resection.

UR - http://www.scopus.com/inward/record.url?scp=84890547660&partnerID=8YFLogxK

U2 - 10.1111/hpb.12066

DO - 10.1111/hpb.12066

M3 - Review article

C2 - 23461716

AN - SCOPUS:84890547660

VL - 16

SP - 12

EP - 19

JO - HPB

JF - HPB

SN - 1365-182X

IS - 1

ER -

Use of pre-operative steroids in liver resection: a systematic review and meta-analysis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this