Use of pre-operative steroids in liver resection: a systematic review and meta-analysis

Arthur J. Richardson; Jerome M. Laurence; Vincent W. T. Lam

doi:10.1111/hpb.12066

Use of pre-operative steroids in liver resection: a systematic review and meta-analysis

Arthur J. Richardson^*, Jerome M. Laurence, Vincent W. T. Lam

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

Background: By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications. Methods: A systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed. Results: Five RCTs were identified including a total of 379 patients. Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. There was a trend towards a lower incidence of post-operative complications and prothrombin time (PT), but this did not reach statistical significance. Conclusion: Pre-operative steroids may be associated with a clinically significant benefit in liver resection.

Original language	English
Pages (from-to)	12-19
Number of pages	8
Journal	HPB
Volume	16
Issue number	1
DOIs	https://doi.org/10.1111/hpb.12066
Publication status	Published - 1 Jan 2014
Externally published	Yes

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10.1111/hpb.12066

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title = "Use of pre-operative steroids in liver resection: a systematic review and meta-analysis",

abstract = "Background: By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications. Methods: A systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed. Results: Five RCTs were identified including a total of 379 patients. Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. There was a trend towards a lower incidence of post-operative complications and prothrombin time (PT), but this did not reach statistical significance. Conclusion: Pre-operative steroids may be associated with a clinically significant benefit in liver resection.",

author = "Richardson, {Arthur J.} and Laurence, {Jerome M.} and Lam, {Vincent W. T.}",

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T1 - Use of pre-operative steroids in liver resection

T2 - a systematic review and meta-analysis

AU - Richardson, Arthur J.

AU - Laurence, Jerome M.

AU - Lam, Vincent W. T.

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Y1 - 2014/1/1

N2 - Background: By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications. Methods: A systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed. Results: Five RCTs were identified including a total of 379 patients. Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. There was a trend towards a lower incidence of post-operative complications and prothrombin time (PT), but this did not reach statistical significance. Conclusion: Pre-operative steroids may be associated with a clinically significant benefit in liver resection.

AB - Background: By attenuating the systemic inflammatory response to major surgery, the pre-operative administration of steroids may reduce the incidence of complications. Methods: A systematic review was conducted to identify randomized controlled trials (RCT) comparing pre-operative steroid administration with placebo during a liver resection. Meta-analyses were performed. Results: Five RCTs were identified including a total of 379 patients. Pre-operative steroids were associated with statistically significant reductions in the levels of serum bilirubin and interleukin 6 (IL-6) on post-operative day one. There was a trend towards a lower incidence of post-operative complications and prothrombin time (PT), but this did not reach statistical significance. Conclusion: Pre-operative steroids may be associated with a clinically significant benefit in liver resection.

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Use of pre-operative steroids in liver resection: a systematic review and meta-analysis

Abstract

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