Use of the CogState brief battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study

Yen Ying Lim*, Kathryn A. Ellis, Karra Harrington, David Ames, Ralph N. Martins, Colin L. Masters, Christopher Rowe, Greg Savage, Cassandra Szoeke, David Darby, Paul Maruff, The AIBL Research Group

*Corresponding author for this work

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The aim of this study was to validate the CogState Brief Battery, which assesses psychomotor, attentional, working memory, and visual learning functions, in healthy older people and in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD), enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. In healthy older adults, weak relationships between demographic variables (e.g., education, depression) and cognitive performance were observed. In AD and MCI groups, the magnitude of impairment was greatest for tasks of working memory and memory, with a negative influence of apolipoprotein E ε4 status on learning but not working memory. These results suggest that the CogState Brief Battery can be used to screen for AD-related cognitive changes.

Original languageEnglish
Pages (from-to)345-358
Number of pages14
JournalJournal of Clinical and Experimental Neuropsychology
Volume34
Issue number4
DOIs
Publication statusPublished - 2012

Keywords

  • Alzheimer’s disease
  • CogState
  • Australian imaging
  • Biomarkers and Lifestyle study
  • Apolipoprotein E ε4
  • Cognitive testing

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