Utilization of small pediatric donor kidneys: a decision analysis

Jerome M. Laurence, Charbel Sandroussi, Vincent W. T. Lam, Henry C. C. Pleass, Guy D. Eslick, Richard D. M. Allen

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Background: Given the disparity between static supply and increasing demand for organs, the greatest challenge is broadening access to the benefits of kidney transplantation. Organs from small deceased pediatric donors are a potentially underused resource. These may be transplanted as en bloc kidney transplants (EBKTs) to one recipient or as single kidney transplants (SKTs) to two recipients, albeit with an increased risk of graft failure. Methods: A systematic literature search identified data on transplant outcomes for recipients of organs from small pediatric deceased donors. A decision analysis model was constructed to allow the outcome in life years (LY) to be predicted for patients with end-stage kidney disease on the transplant waiting list depending on whether they received EBKT or SKT. Results: At all recipient ages, the projected LY of both recipients of an SKT was greater than the projected LY of an EBKT recipient. The net estimated gain in LY associated with the SKT technique was greatest for recipients aged 20 to 39 years (14.3 years) and lowest for recipients aged 60 to 74 years (3.36 years). Only for recipients of organs from donors weighing less than 10 kg, there was an estimated net loss of LY associated with the SKT technique across all recipient age groups. Conclusions: There is a greater gain in overall life expectancy using SKTs, because this technique yields two recipients per donor, which more than compensates for the increased risk of graft failure.

Original languageEnglish
Pages (from-to)1110-1113
Number of pages4
JournalTransplantation
Volume91
Issue number10
DOIs
Publication statusPublished - 27 May 2011
Externally publishedYes

Keywords

  • Deceased donor
  • Decision analysis
  • En bloc kidney transplant
  • Kidney transplantation

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