Validation of models for the diffusion weighted MR signal in brain white matter

Els Fieremans*, Yves De Deene, Ignace Lemahieu

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

The diffusion weighted MR-signal attenuation in brain white matter is not mono-exponential. A bi-exponential model has been proposed since this fits the data well. We have modeled the diffusion weighted MR-signal by Monte Carlo simulations in a fiber geometry similar to brain white matter. Although the bi-exponential model fitted the data very well, the fitted diffusion coefficients and fractions did not converge to the simulated values in the intra and extra cellular space. However, fitting the cumulant expansion form terminated after the Nth order term to the data results in accurate fits for the diffusion coefficient and kurtosis.

Original languageEnglish
Title of host publication2008 5th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationfrom nano to macro, proceedings, ISBI
Place of PublicationPiscataway, NJ
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages915-918
Number of pages4
ISBN (Print)9781424420032
DOIs
Publication statusPublished - 2008
Externally publishedYes
Event2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI - Paris, France
Duration: 14 May 200817 May 2008

Other

Other2008 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI
CountryFrance
CityParis
Period14/05/0817/05/08

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