Validation of the Asia Pacific Colorectal Screening (APCS) score in a Western population: An alternative screening tool

Crispin Corte*, Lora Zhang, Ji Chen, Sean Westbury, James Shaw, Khay Guan Yeoh, Rupert Leong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Background and Aim: Colorectal cancer (CRC) screening is based on colonoscopy or fecal occult blood tests, but is imperfect and costly. The Asia Pacific Colorectal Screening Score (APCS) is derived from age, sex, family history of CRC, and smoking history and has been validated in Asian populations. Validation in a Western population is, however, yet to be tested. Methods: In a teaching hospital, patients underwent colonoscopy for standard indications and screening over 18months. Data was collected on age, sex, family history of CRC, smoking, weight, ethnicity, and symptoms. Evaluation of the APCS to predict colonoscopy findings (polyps, adenoma, high risk adenoma, and CRC) was performed. Results: A total of 645 patients were prospectively recruited (46.7% male, median age 57years); 17.8% were average risk (AR), 50.9% were moderate risk (MR), and 31.3% high risk (HR) on APCS. High risk adenomas (AA) were seen in 14.9% of the HR, 5.2% MR, and 0.9% LR patients, P<0.0001. Comparing HR and MR to AR patients demonstrated significantly elevated relative risk (RR) for AA: 17.1 (95% confidence interval [CI] 2.4-123; P=0.0001), and adenoma 6.0 (0.80-44.3; P=0.044). Comparing HR to MR groups for AA, the RR was 2.87 (1.62-5.06; P=0.0001). Symptoms did not predict findings (odds ratio [OR]: 1.06 [0.75-1.48]; P=0.75). Body mass index (BMI) <20kg/m2 was protective against colonic polyps (OR: 0.28, 95%CI: 0.11-0.74; P=0.010), adenoma (0.08, 0.01-0.62; P=0.015), and AA (perfect prediction, OR 2.35×10-8). Conclusions: APCS predicts colonic findings in a Western population, to a greater extent than in Asians, independent to symptoms. Low body weight carries a strong protective effect against colonic neoplasia.

Original languageEnglish
Pages (from-to)370-375
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number2
Publication statusPublished - 1 Feb 2016
Externally publishedYes


  • Colorectal cancer: clinical research<gastroenterology
  • Colorectal cancer: epidemiology and surveillance<gastroenterology
  • Endoscopy: colon<gastroenterology
  • Screening and diagnosis<gastroenterology


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