Vascular architecture: is it a helpful histopathological biomarker for hepatocellular carcinoma?

Fabio Grizzi*, Barbara Franceschini, Barbara Fiamengo, Carlo Russo, Nicola Dioguardi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Hepatocellular carcinoma (HCC) remains one of the major public health problems throughout the world. Although originally associated with tumorigenic processes, liver angiogenesis has also been observed in the context of different liver inflammatory, fibrotic, and ischemic conditions. Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue, and discuss why this parameter might provide additional information regarding cancer behavior. The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation, and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process.

Original languageEnglish
Pages (from-to)217-220
Number of pages4
JournalJournal of Zhejiang University. Science. B.
Issue number4
Publication statusPublished - 1 Jan 2007
Externally publishedYes


  • liver
  • angiogenesis
  • cancer
  • fractals
  • geometry
  • biomarkers


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