Vascular inflammation imaging with 18F-FDG PET/CT

when to image?

Leon J. Menezes, Carl W. Kotze, Brian F. Hutton, Raymondo Endozo, John C. Dickson, Ian Cullum, Syed W. Yusuf, Peter J. Ell, Ashley M. Groves

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    Abstract

    We prospectively investigated the ideal imaging time to measure vascular uptake after injection of 18F-FDG. Methods: A total of 17 patients with atherosclerotic abdominal aortic aneurysm underwent dynamic abdominal PET/CT using 2-min frames between 45 and 53, 57 and 65, 115 and 123, and 175 and 183 min after injection of 18F-FDG. For each period of dynamic imaging, vessel wall and lumen uptake were measured using the maximum standardized uptake value (SUVmax) and target-tobackground ratio (TBR). Results: No significant difference in TBR across all time points (repeated measures ANOVA, P = 0.206) was observed, despite a significant difference in aortic wall and lumen uptake with time (repeated measures ANOVA, P = 0.02 and P < 0.001, respectively). There was no significant difference between aortic wall uptake at 60 min (SUVmax, 2.15 ± 0.11 SE) and 180 min (SUVmax, 1.99 ± 0.18 SE) (paired t test, P = 0.367). There was a significant difference in lumen uptake at 60 min (SUV max, 2.4 ± 0.11 SE) and 180 min (SUVmax, 1.7 ± 0.1 SE) (paired t test, P = 0.001). There was no significant difference in TBR between 60 min (0.91 ± 0.03) and 180 min (1.01 ± 0.06 SE) (paired t test, P = 0.131). With increasing delayed imaging, there was increasing variability (SE) in the SUVmax for the aortic wall and TBRs. Conclusion: There was no significant advantage in imaging at 3 h over 1 h after 18F-FDG injection.

    Original languageEnglish
    Pages (from-to)854-857
    Number of pages4
    JournalJournal of Nuclear Medicine
    Volume50
    Issue number6
    DOIs
    Publication statusPublished - 1 Jun 2009

    Keywords

    • F-FDG
    • Aneurysm
    • Atherosclerosis
    • Methodology
    • PET/CT
    • Positron emission tomography
    • Radiotracer tissue kinetics
    • Vascular

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  • Cite this

    Menezes, L. J., Kotze, C. W., Hutton, B. F., Endozo, R., Dickson, J. C., Cullum, I., ... Groves, A. M. (2009). Vascular inflammation imaging with 18F-FDG PET/CT: when to image? Journal of Nuclear Medicine, 50(6), 854-857. https://doi.org/10.2967/jnumed.108.061432