TY - JOUR
T1 - Vascular risk to late-life depression
T2 - Evidence from a longitudinal community study
AU - Hickie, Ian
AU - Simons, Leon
AU - Naismith, Sharon
AU - Simons, Judith
AU - McCallum, John
AU - Pearson, Kerrie
PY - 2003/2
Y1 - 2003/2
N2 - Objective: To determine prospectively relationships between minor cerebrovascular episodes and depressive symptoms in a community cohort of older persons. Method: In 1988-1989, baseline measurements of vascular risk factors and depressive symptoms were obtained in older community residents (mean age = 67). At 10-year follow-up, three subgroups of subjects still residing in the community were re-assessed: those who had suffered a transient ischaemic attack (TIA) (n = 16) in the intervening period; those with hypertension but no TIAs (n = 38); and, those with neither TIAs nor hypertension (n = 40). Results: Of the 16 persons with depressive symptoms at 10-year follow-up, only three had reported depressive symptoms initially. Subjects who had experienced TIAs during the longitudinal phase had higher rates of depressive symptoms than the subjects from the other two groups (38% vs 13%, p < 0.05). Conclusions: This study supports the notion that cerebrovascular incidents predispose to late-onset depression in older persons residing in the community. Intrinsically, this provides epidemiological support for the validity of the concept of 'vascular depression'.
AB - Objective: To determine prospectively relationships between minor cerebrovascular episodes and depressive symptoms in a community cohort of older persons. Method: In 1988-1989, baseline measurements of vascular risk factors and depressive symptoms were obtained in older community residents (mean age = 67). At 10-year follow-up, three subgroups of subjects still residing in the community were re-assessed: those who had suffered a transient ischaemic attack (TIA) (n = 16) in the intervening period; those with hypertension but no TIAs (n = 38); and, those with neither TIAs nor hypertension (n = 40). Results: Of the 16 persons with depressive symptoms at 10-year follow-up, only three had reported depressive symptoms initially. Subjects who had experienced TIAs during the longitudinal phase had higher rates of depressive symptoms than the subjects from the other two groups (38% vs 13%, p < 0.05). Conclusions: This study supports the notion that cerebrovascular incidents predispose to late-onset depression in older persons residing in the community. Intrinsically, this provides epidemiological support for the validity of the concept of 'vascular depression'.
KW - Cerebrovascular risk
KW - Depression
KW - Late-onset
KW - Transient ischaemic attack
KW - Vascular depression
UR - http://www.scopus.com/inward/record.url?scp=0346034586&partnerID=8YFLogxK
U2 - 10.1046/j.1440-1614.2003.01105.x
DO - 10.1046/j.1440-1614.2003.01105.x
M3 - Article
C2 - 12534658
AN - SCOPUS:0346034586
SN - 0004-8674
VL - 37
SP - 62
EP - 65
JO - Australian and New Zealand Journal of Psychiatry
JF - Australian and New Zealand Journal of Psychiatry
IS - 1
ER -