Verbal memory impairment after left insular cortex infarction

Facundo Manes*, Jane Springer, Ricardo Jorge, Robert G. Robinson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


PET studies have shown an association between changes in blood flow in the insular cortex and verbal memory. This study compared verbal memory profiles between a group of four right handed patients with right insular infarction and a group of six right handed patients with left insular infarction. Patient groups were comparable in age, education, and sex. Patients were administered memory tests about 4-8 weeks poststroke. Patients with left insular lesions showed significantly poorer immediate and delayed verbal memory as measured by story A of the WMS-R logical memory I (t = -2.73, p < 0.03) and logical memory II (t = -4.1, p < 0.004) subtests as well as the CERAD word list memory (delayed recall) (t = -2.4, p < 0.05). These findings indicate that left insular damage is associated with poorer performance on verbal memory tasks. The findings suggest that the insula may be part of a functional network that mediates verbal memory.

Original languageEnglish
Pages (from-to)532-534
Number of pages3
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number4
Publication statusPublished - Oct 1999
Externally publishedYes


  • Insula
  • Memory
  • Stroke


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