Viruses in glioblastoma: an update on evidence and clinical trials

Bavani Gunasegaran; Caroline L. Ashley; Felix Marsh-Wakefield; Gilles J. Guillemin; Benjamin Heng

doi:10.1038/s44276-024-00051-z

Viruses in glioblastoma: an update on evidence and clinical trials

Bavani Gunasegaran, Caroline L. Ashley, Felix Marsh-Wakefield, Gilles J. Guillemin, Benjamin Heng

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Abstract

Background: Glioblastoma (GB) is a lethal and aggressive brain tumour. While molecular characteristics of GB is studied extensively, the aetiology of GB remains uncertain. The interest in exploring viruses as a potential contributor to the development of GB stems from the notion that viruses are known to play a key role in pathogenesis of other human cancers such as cervical cancer. Nevertheless, the role of viruses in GB remains controversial.

Methods: This review delves into the current body of knowledge surrounding the presence of viruses in GB as well as provide updates on clinical trials examining the potential inclusion of antiviral therapies as part of the standard of care protocol.

Conclusions: The review summarises current evidences and important gaps in our knowledge related to the presence of viruses in GB.

Original language	English
Article number	33
Pages (from-to)	1-21
Number of pages	21
Journal	BJC reports
Volume	2
Issue number	1
DOIs	https://doi.org/10.1038/s44276-024-00051-z
Publication status	Published - 19 Apr 2024

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Copyright the Author(s) 2024. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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AU - Heng, Benjamin

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N2 - Background: Glioblastoma (GB) is a lethal and aggressive brain tumour. While molecular characteristics of GB is studied extensively, the aetiology of GB remains uncertain. The interest in exploring viruses as a potential contributor to the development of GB stems from the notion that viruses are known to play a key role in pathogenesis of other human cancers such as cervical cancer. Nevertheless, the role of viruses in GB remains controversial.Methods: This review delves into the current body of knowledge surrounding the presence of viruses in GB as well as provide updates on clinical trials examining the potential inclusion of antiviral therapies as part of the standard of care protocol.Conclusions: The review summarises current evidences and important gaps in our knowledge related to the presence of viruses in GB.

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Viruses in glioblastoma: an update on evidence and clinical trials

Abstract

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